{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T08:26:06Z","timestamp":1760171166934,"version":"3.37.3"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,9,29]],"date-time":"2020-09-29T00:00:00Z","timestamp":1601337600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000355","name":"Bupa Foundation","doi-asserted-by":"publisher","award":["RG140045"],"award-info":[{"award-number":["RG140045"]}],"id":[{"id":"10.13039\/501100000355","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Because bacterial cystitis is common in women with refractory detrusor overactivity, the aim was to compare the efficacy of 6 weeks of rotating antibiotics versus placebo, in conjunction with an anticholinergic, in controlling the symptoms of urge incontinence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a multicenter phase IIb double\u2010blinded randomized placebo\u2010controlled trial, women with urodynamically proven refractory detrusor overactivity were randomized in a 2:1 ratio of antibiotics versus placebo for 6 weeks, in addition to darifenacin for 6 months. Any woman with disabling cystitis symptoms was given appropriate antibiotics (\u201cclinical override\u201d). The primary outcome was the degree of urge incontinence change at 6 weeks and 6 months on 24\u2010h\u00a0pad test. Secondary outcomes were changes in leaks and voids per day measured on 3\u2010day bladder diary and quality of life measures. Microbiological data were collected at all visits.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Although 278 women were screened, only 36 were randomized and 33 (91.7%) completed the trial. Leakage on 24\u2010h\u00a0pad test decreased at 6 months by 75\u2009g in patients receiving antibiotics versus 35\u2009g in placebo. Cure of urge incontinence occurred at 6 months in 10\/21 (48%) of antibiotics versus 2\/12 (17%) of placebo. Clinical override, necessitating treatment of cystitis, occurred in 41.6% of placebo versus 16.7% of the antibiotic group by 6 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Despite the small sample size, the study showed a significant reduction in pad leakage and leaks per day over 24\u2009h\u00a0in the active treatment group over a 6\u2010month period. Nearly half of patients on placebo had disabling urinary tract infection symptoms that required clinical override treatment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.24525","type":"journal-article","created":{"date-parts":[[2020,9,29]],"date-time":"2020-09-29T12:28:21Z","timestamp":1601382501000},"page":"158-167","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Effect of antibiotics on urine leakage in women with refractory detrusor overactivity: A phase IIb randomized trial"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3974-3632","authenticated-orcid":false,"given":"Zhuoran","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Urogynaecology, St. George Hospital University of New South Wales Sydney New South Wales 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