{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T05:53:32Z","timestamp":1777096412585,"version":"3.51.4"},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,10,12]],"date-time":"2020-10-12T00:00:00Z","timestamp":1602460800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Neurogenic bladder (NB) post\u2010meningomyelocele (MMC) repair is a major challenge and needs lifelong follow\u2010up. Many cytokines have been implicated in the pathogenesis of NB. To avoid repeated urodynamic studies (UDS) and renal scans, we studied urinary tissue inhibitors of metalloproteinases\u20102 (TIMP\u20102) levels and correlated with urodynamic profiles to establish their efficacy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Prospective case\u2013control study on children between 6 months to 12 years of age, who were at least 6 months post\u2010MMC repair and had NB on UDS. Patients were evaluated under 4 cohorts of 20 patients each: Group A (NB on treatment), Group B (NB not on treatment), Group C (no NB), and Group D (Controls). All groups underwent radiofrequency thermocoagulation, urine culture, ultrasonography. Urine samples were stored at \u22128\u00b0C and analyzed using a validated Human ELISA kit for TIMP\u20102.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighty\u00a0patients with a mean age of 3.54\u2009\u00b1\u20092.1 years were studied. A common ultrasound finding was a thickened urinary bladder (33.3%). All UDS parameters showed a statistically significant differences between groups with NB (Groups A and B) and a group without NB (Group C). Analysis of TIMP\u20102 levels between individual groups was statistically significant. The area under the receiver operating characteristic curve between urinary TIMP\u20102 and cystometric parameters indicated that urinary TIMP\u20102 levels are highly diagnostic of NB. TIMP\u20102 value of 358.5\u2009pg\/ml was found to be the least value with 93.5 sensitivity and 86.2% specificity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study highlights the potential of urinary marker TIMP\u20102 as noninvasive and cost\u2010effective test to initially diagnose and predict the progression of disease in NBs with reasonable sensitivity and specificity.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.24528","type":"journal-article","created":{"date-parts":[[2020,10,12]],"date-time":"2020-10-12T20:49:21Z","timestamp":1602535761000},"page":"168-175","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["TIMP\u20102 as a\u00a0noninvasive urinary marker for predicting neurogenic bladder in patients under follow\u2010up for spina bifida"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9355-8510","authenticated-orcid":false,"given":"Shubhalaxmi","family":"Nayak","sequence":"first","affiliation":[{"name":"Department of Pediatric Surgery Post Graduate Institute of Medical Education and Research (PGIMER)  Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4161-0492","authenticated-orcid":false,"given":"Monika","family":"Bawa","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Post Graduate Institute of Medical Education and Research (PGIMER)  Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ravi P.","family":"Kanojia","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Post Graduate Institute of Medical Education and Research (PGIMER)  Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0850-3118","authenticated-orcid":false,"given":"Arnab","family":"Pal","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Post Graduate Institute of Medical Education and Research (PGIMER)  Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anu","family":"Jain","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Post Graduate Institute of Medical Education and Research (PGIMER)  Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ram","family":"Samujh","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Post Graduate Institute of Medical Education and Research (PGIMER)  Chandigarh 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