{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T15:58:18Z","timestamp":1765727898862,"version":"3.37.3"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,11,10]],"date-time":"2020-11-10T00:00:00Z","timestamp":1604966400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>This prospective study aimed to compare the clinical outcomes between the use of Erbium:YAG (Er:YAG) laser in a nonablative mode, to the use of the pharmacological treatment of oral tadalafil for the treatment of chronic prostatitis\/chronic pelvic pain syndrome (CP\/CPPS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The laser group received two sessions of Erbium:YAG laser, administered intraurethrally in a long, nonablative train of long pulses (SMOOTH\u2122 mode), applied at the level of the male prostatic urethra. Tadalafil group received oral tadalafil at a dose of 5\u2009mg\/day, consecutively for 2 months. Effectiveness was assessed using the International Prostate Symptom Score (IPSS) questionnaire, VAS (visual analogue scale) pain score, and maximum urethral flow at follow\u2010up visits up to 12 months after initiating treatment. Adverse effects were recorded after each treatment and follow\u2010up sessions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The results show a significant decrease in the IPSS score in both groups up to the 12\u2010month\u00a0follow\u2010up. The increase in Q\u2010max was evident up to 3\u2010months follow\u2010up in the tadalafil group and up to 6 months in the laser group. The decrease in the VAS pain score was also significant in both treatment groups, lasting up to 3 months in the tadalafil group and up to 6 months in the laser group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The nonablative Er:YAG SMOOTH\u2122\u00a0laser seems to be a promising treatment for this widely occurring condition. More studies are needed to confirm its safety and efficacy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.24551","type":"journal-article","created":{"date-parts":[[2020,11,10]],"date-time":"2020-11-10T22:31:33Z","timestamp":1605047493000},"page":"278-285","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Nonablative transurethral Erbium:YAG laser treatment for chronic prostatitis\/chronic pelvic pain syndrome: A prospective comparative study"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8852-9010","authenticated-orcid":false,"given":"Adri\u00e1n","family":"Gaspar","sequence":"first","affiliation":[{"name":"Uroclinica  Mendoza Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joaqu\u00edn","family":"Silva","sequence":"additional","affiliation":[{"name":"Uroclinica  Mendoza Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo","family":"Silva","sequence":"additional","affiliation":[{"name":"Uroclinica  Mendoza Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ra\u00fal","family":"Anchelerguez","sequence":"additional","affiliation":[{"name":"Uroclinica  Mendoza Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Prats","sequence":"additional","affiliation":[{"name":"Uroclinica  Mendoza Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro","family":"Sagaz","sequence":"additional","affiliation":[{"name":"Uroclinica  Mendoza Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo","family":"Rovere","sequence":"additional","affiliation":[{"name":"Uroclinica  Mendoza Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauricio","family":"Alastra","sequence":"additional","affiliation":[{"name":"Uroclinica  Mendoza Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Pino","sequence":"additional","affiliation":[{"name":"Uroclinica  Mendoza Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro","family":"Jauregui","sequence":"additional","affiliation":[{"name":"Uroclinica  Mendoza Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcos","family":"Farrugia","sequence":"additional","affiliation":[{"name":"Uroclinica  Mendoza Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabricio","family":"Villaroel","sequence":"additional","affiliation":[{"name":"Uroclinica  Mendoza Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Guareschi","sequence":"additional","affiliation":[{"name":"Uroclinica  Mendoza Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maximiliano","family":"Vega","sequence":"additional","affiliation":[{"name":"Uroclinica  Mendoza Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuel","family":"Biasiori","sequence":"additional","affiliation":[{"name":"Uroclinica  Mendoza Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuel","family":"Moyano","sequence":"additional","affiliation":[{"name":"Uroclinica  Mendoza Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"La Rosa","sequence":"additional","affiliation":[{"name":"Uroclinica  Mendoza Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irena","family":"Hreljac","sequence":"additional","affiliation":[{"name":"Department of Clinical Affairs Fotona d.o.o.  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