{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T10:59:46Z","timestamp":1790420386147,"version":"4.1.0"},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,1,7]],"date-time":"2021-01-07T00:00:00Z","timestamp":1609977600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the clinical, urodynamic efficacy, and safety of mirabegron in patients with neurogenic detrusor overactivity (NDO) consequent to traumatic spinal cord injury (SCI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This prospective cohort study was performed between January 2018 and July 2019 and included adult patients with stable traumatic suprasacral SCI, performing clean intermittent catheterization (CIC), and demonstrating NDO on urodynamic study (UDS). A 3\u2010day bladder diary was made at the baseline after which all patients were started on Mirabegron 50\u2009mg. They were followed up at 6 weeks with a repeat bladder diary and UDS which were compared with those at the baseline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 30 patients (4 females, 26 males, mean age: 30.07 years) were included. After 6 weeks of treatment, 5 out of the 29 incontinent patients became completely dry. The mean frequency of CIC decreased from 6.63 at the baseline to 5.37 at 6 weeks (<jats:italic>p<\/jats:italic>\u2009=\u2009.002), the mean CIC volume increased from 275\u2009ml\u00a0to 341\u2009ml (<jats:italic>p<\/jats:italic>\u2009=\u2009.0002), the mean number of incontinence episodes in between CIC reduced from 3.97 to 2.27 (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.0001) and time from CIC to leakage increased from 1.73\u2009h\u00a0to 2.75\u2009h (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.0001). The mean cystometric capacity increased from 348\u2009ml to 406\u2009ml (<jats:italic>p<\/jats:italic>\u2009=\u2009.008) and the maximum amplitude of NDO decreased from 54\u2009cm H<jats:sub>2<\/jats:sub>O to 41\u2009cm H<jats:sub>2<\/jats:sub>O\u00a0(<jats:italic>p<\/jats:italic>\u2009=\u2009.005) at 6 weeks. Only two patients reported new onset dry mouth. No major adverse events were noted and none discontinued treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Mirabegron is efficacious and safe in patients with NDO consequent to traumatic SCI.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.24604","type":"journal-article","created":{"date-parts":[[2021,1,10]],"date-time":"2021-01-10T17:52:12Z","timestamp":1610301132000},"page":"666-671","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Efficacy and safety of mirabegron for the treatment of neurogenic detrusor overactivity resulting from traumatic spinal cord injury: A prospective study"],"prefix":"10.1002","volume":"40","author":[{"given":"Pawan","family":"Vasudeva","sequence":"first","affiliation":[{"name":"Department of Urology &amp; Renal transplant V.M. Medical College and Safdarjang Hospital  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishnu","family":"Prasad","sequence":"additional","affiliation":[{"name":"Department of Urology &amp; Renal transplant V.M. Medical College and Safdarjang Hospital  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0231-6645","authenticated-orcid":false,"given":"Siddharth","family":"Yadav","sequence":"additional","affiliation":[{"name":"Department of Urology &amp; Renal transplant V.M. Medical College and Safdarjang Hospital  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9811-5492","authenticated-orcid":false,"given":"Niraj","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Urology &amp; Renal transplant V.M. Medical College and Safdarjang Hospital  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kumar","family":"Saurav","sequence":"additional","affiliation":[{"name":"Department of Urology &amp; Renal transplant V.M. Medical College and Safdarjang Hospital  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y. M.","family":"Prashanth","sequence":"additional","affiliation":[{"name":"Department of Urology &amp; Renal transplant V.M. Medical College and Safdarjang Hospital  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijay","family":"Tyagi","sequence":"additional","affiliation":[{"name":"Department of Urology &amp; Renal transplant V.M. Medical College and Safdarjang Hospital  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,1,7]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.2147\/JN.S143236"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ucl.2010.07.004"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2009.04.028"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/sc.2013.19"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/sc.2012.164"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12894-017-0216-4"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-014-0271-z"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.23566"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.23774"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41393-019-0350-9"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.23124"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/1756287215614237"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2012.10.016"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2012.10.017"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/sc.2015.195"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2013.11.010"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.22373"}],"container-title":["Neurourology and Urodynamics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nau.24604","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/nau.24604","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nau.24604","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T09:28:51Z","timestamp":1692696531000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/nau.24604"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,7]]},"references-count":17,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["10.1002\/nau.24604"],"URL":"https:\/\/doi.org\/10.1002\/nau.24604","archive":["Portico"],"relation":{},"ISSN":["0733-2467","1520-6777"],"issn-type":[{"value":"0733-2467","type":"print"},{"value":"1520-6777","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,7]]},"assertion":[{"value":"2020-11-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}