{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T02:26:50Z","timestamp":1740104810848,"version":"3.37.3"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,2,19]],"date-time":"2021-02-19T00:00:00Z","timestamp":1613692800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Interstitial cystitis (IC) is a chronic pain syndrome that is characterized by suprapubic pain upon bladder filling. <jats:italic>Bletilla striata<\/jats:italic>, a well\u2010known traditional Chinese herb with established efficacy in wound healing and anti\u2010inflammation, was hypothesized to improve the symptoms of IC possibly though forming a physical barrier that could isolate the bladder tissue from irritants. This study was conducted to evaluate the beneficial effects of intravesical treatment with <jats:italic>B. striata<\/jats:italic> extract solution (BSES) on visceral pain and bladder function of rats with zymosan\u2010induced IC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty female rats were randomly divided into control group, zymosan\u2010induced cystitis rats treated with normal saline (Z\u2009+\u2009NS), and zymosan\u2010induced cystitis rats treated with BSES (Z\u2009+\u2009BSES). All rats underwent evaluation for abdominal withdrawal reflex (AWR) scores to assess visceral hypersensitivity, cystometrography, and electromyogram (EMG) of both external urethral sphincter and bladder detrusor. Data were analyzed by one way analysis of variance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The Z\u2009+\u2009NS group had an increased visceral hypersensitivity as compared to control group. Rats treated with BSES (Z\u2009+\u2009BSES group) had decreased AWR scores and amplitude of bladder detrusor\u2010EMG. Besides, BSES treatment improved overactive bladder with significant effects on the extend of micturition interval and increase of storage of urine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Intravesical instillation of BSES can significantly alleviate zymosan\u2010induced visceral hypersensitivity and bladder overactivity associated with IC. This study suggested that intravesical instillation with BSES might be a promising treatment for IC.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.24630","type":"journal-article","created":{"date-parts":[[2021,2,20]],"date-time":"2021-02-20T23:06:29Z","timestamp":1613862389000},"page":"763-770","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Beneficial effect of <i>Bletilla striata<\/i> extract solution on zymosan\u2010induced interstitial cystitis in rat"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7193-7448","authenticated-orcid":false,"given":"Yi\u2010Ching","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Chang Gung Memorial Hospital, Linkou Medical Center Taoyuan Taiwan"},{"name":"College of Medicine Chang Gung University Taoyuan 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