{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T23:28:07Z","timestamp":1780529287088,"version":"3.54.1"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>To evaluate the relationship between serum testosterone (T) levels and artificial urinary sphincter (AUS) cuff erosion in a population of incontinent men who underwent AUS placement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective analysis of our single\u2010surgeon AUS database was performed to identify men with T levels within 24 months of AUS placement. Men were stratified into two groups based on serum testosterone: low\u00a0serum testosterone (LT) (&lt;280\u2009ng\/dl) and\u00a0normal\u00a0serum testosterone (NT) (&gt;280\u2009ng\/dl). Multivariable analysis was performed to control for risk factors. The outcome of interest was the incidence of and time to spontaneous urethral cuff erosion; other risk factors for cuff erosion were also evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 161 AUS patients with serum testosterone\u00a0levels, 84 (52.2%) had\u00a0LT\u00a0(mean:\u00a0136.8\u2009ng\/dl, <jats:italic>SD<\/jats:italic>: 150.4\u2009ng\/dl)\u00a0and 77 (47.8%) had NT (mean: 455.8\u2009ng\/dl, <jats:italic>SD<\/jats:italic>: 197.3\u2009ng\/dl). Cuff erosion was identified in 42 men (26.1%) at a median of 7.1 months postoperatively (interquartile range:\u00a03.6\u201313.4 months), most of whom (30\/42, 71.4%) were testosterone\u00a0deficient. LT\u00a0levels were less common (54\/119, 45.4%) in the non\u2010erosion cohort (<jats:italic>p<\/jats:italic>\u2009=\u20090.004). Men with low T were nearly three times as likely to suffer AUS erosion than men with normal T (odds ratio\u2009=\u20092.519,\u00a0<jats:italic>p<\/jats:italic>\u2009=\u20090.021). LT level was the only factor associated with AUS erosion on multivariable analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>LT\u00a0is an independent risk factor for AUS cuff erosion. Men with LT are more likely to present with cuff erosion, but there is no difference in time to erosion.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.24663","type":"journal-article","created":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T14:30:22Z","timestamp":1617287422000},"page":"1035-1041","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Most men with artificial urinary sphincter cuff erosion have low serum testosterone levels"],"prefix":"10.1002","volume":"40","author":[{"given":"Avery R.","family":"Wolfe","sequence":"first","affiliation":[{"name":"Department of Urology University of Texas Southwestern Medical Center Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas M.","family":"Ortiz","sequence":"additional","affiliation":[{"name":"Department of Urology University of Texas Southwestern Medical Center Dallas Texas 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