{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T09:48:51Z","timestamp":1785836931113,"version":"3.56.0"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,4,8]],"date-time":"2021-04-08T00:00:00Z","timestamp":1617840000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Sacral neuromodulation (SNM) and Botulinum toxin A (BoNT\u2010A) injections are well\u2010known third\u2010line treatment options in patients with refractory overactive bladder (OAB). Our aim is to evaluate the success rate of SNM in patients who received prior therapy with BoNT\u2010A injections.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All patients with OAB symptoms referred for SNM between 2006 and 2019 were included. History taking and 3\u2010day voiding diaries assessed the complaints and suitability for SNM. The success rate of SNM in patients who received prior BoNT\u2010A was compared with BoNT\u2010A naive patients. Success was defined as an improvement of 50% or greater in voiding diary parameters. Satisfaction was registered at their most recent visit.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 263 patients underwent SNM test stimulation, of which 75 (16 male\/57 female) received prior BoNT\u2010A and 188 (46 male\/142 female) were BoNT\u2010A naive. Success rate for SNM in BoNT\u2010A naive patients was 72.9% and in BoNT\u2010A patients 66.7% (<jats:italic>p<\/jats:italic>\u2009=\u20090.316). Success rate after \u22642 BoNT\u2010A injections was 68.5%, compared to 61.1% after \u22653 injections (<jats:italic>p<\/jats:italic>\u2009&gt;\u2009 0.05). Success rate in patients perceiving lack of efficacy of BoNT\u2010A was 67.4% (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05), subjected to temporary CISC was 73.7% (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05) and with temporary effect of BoNT\u2010A was 50% (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05). In 86% of BoNT\u2010A patients the system was still activated and used to their satisfaction at their last follow\u2010up visit (mean FU, 40.70 months).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>SNM in patients with refractory OAB who failed prior BoNT\u2010A is an excellent approach. The number of injections nor reason of BoNT\u2010A discontinuation have predictive value for success with SNM.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.24670","type":"journal-article","created":{"date-parts":[[2021,4,8]],"date-time":"2021-04-08T08:23:20Z","timestamp":1617870200000},"page":"1120-1125","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Sacral neuromodulation in patients with refractory overactive bladder symptoms after failed Botulinum toxin therapy: Results in a large cohort of patients"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9883-1870","authenticated-orcid":false,"given":"Mathias","family":"Reekmans","sequence":"first","affiliation":[{"name":"Department of Urology Maastricht University Medical Center+ (MUMC+)  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janine M. W.","family":"Janssen","sequence":"additional","affiliation":[{"name":"Department of Urology Maastricht University Medical Center+ (MUMC+)  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Desiree M. J.","family":"Vrijens","sequence":"additional","affiliation":[{"name":"Department of Urology Maastricht University Medical Center+ (MUMC+)  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martijn A. C.","family":"Smits","sequence":"additional","affiliation":[{"name":"Department of Urology Maastricht University Medical Center+ (MUMC+)  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gommert A.","family":"van Koeveringe","sequence":"additional","affiliation":[{"name":"Department of Urology Maastricht University Medical Center+ (MUMC+)  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip E. V. A.","family":"Van Kerrebroeck","sequence":"additional","affiliation":[{"name":"Faculty of Health, Medicine and Life Sciences Maastricht University  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,4,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(02)02243-4"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.20705"},{"issue":"4","key":"e_1_2_10_4_1","first-page":"S98","article-title":"Impact of overactive bladder on work productivity in the United States: results from EpiLUTS","volume":"15","author":"Sexton CC","year":"2009","journal-title":"Am J Manag Care"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.2147\/RRU.S102441"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2010.09993.x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euf.2018.03.011"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euf.2018.05.004"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2019.02.038"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.23170"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.2522\/ptj.20080387"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2017.01.037"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2018.03.020"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2007.07.032"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2017.07.010"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2013.07.017"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.23117"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.24326"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.5213\/inj.1938030.015"}],"container-title":["Neurourology and Urodynamics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nau.24670","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/nau.24670","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nau.24670","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T22:52:13Z","timestamp":1693349533000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/nau.24670"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,8]]},"references-count":18,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["10.1002\/nau.24670"],"URL":"https:\/\/doi.org\/10.1002\/nau.24670","archive":["Portico"],"relation":{},"ISSN":["0733-2467","1520-6777"],"issn-type":[{"value":"0733-2467","type":"print"},{"value":"1520-6777","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,8]]},"assertion":[{"value":"2020-11-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}