{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T10:09:24Z","timestamp":1780567764369,"version":"3.54.1"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,5,11]],"date-time":"2021-05-11T00:00:00Z","timestamp":1620691200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>To assess the efficacy of traditional first\u2010line non\u2010antidiuretic pharmacotherapy for nocturia in the real\u2010world outpatient urology setting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively analyzed voiding diaries from adult men treated for lower urinary tract symptoms (LUTS) at an outpatient urology clinic to identify pairs of voiding diaries with \u22651 nocturnal void at baseline and a corresponding follow\u2010up diary completed within 1 year. We compared the odds of nocturia improvement (decrease of \u22651 nocturnal void) in patients started on LUTS pharmacotherapy versus behavioral modification alone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Two hundred and thirteen diary pairs from 93 patients were included. Fifty\u2010seven diary pairs were identified from patients prescribed at least one LUTS drug on the initial visit and 156 diary pairs were identified from patients receiving behavioral modification alone. All standard voiding diary parameters were assessed, and only maximum voided volume differed at baseline (240\u2009ml [interquartile range: 200\u2013330\u2009ml] vs. 280\u2009ml [200\u2013400\u2009ml] with and without pharmacotherapy, respectively, <jats:italic>p<\/jats:italic>\u2009=\u20090.04). The odds of nocturia improvement did not significantly differ between pharmacotherapy and behavioral modification treatment groups (crude odds ratio [OR]: 1.16 [95% confidence interval: 0.63\u20132.16], <jats:italic>p<\/jats:italic>\u2009=\u20090.63; maximum voided volume [MVV]\u2010adjusted OR: 1.19 [0.63\u20132.22], <jats:italic>p<\/jats:italic>\u2009=\u20090.59). In contrast, improvement in 24\u2010h urinary frequency was more likely with pharmacotherapy versus behavioral modification alone (crude OR: 2.36 [1.22\u20134.56], <jats:italic>p<\/jats:italic>\u2009=\u20090.01; MVV\u2010adjusted OR: 2.05 [1.05\u20134.01], <jats:italic>p<\/jats:italic>\u2009=\u20090.04). Results were consistent on subgroup analyses restricted to first diary pairs from each patient.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Despite improvement in 24\u2010h voiding frequency, there was no evidence that adjunctive pharmacotherapy provided a benefit in the treatment of nocturia in men receiving behavioral counseling.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.24692","type":"journal-article","created":{"date-parts":[[2021,5,11]],"date-time":"2021-05-11T16:25:01Z","timestamp":1620750301000},"page":"1133-1139","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Does traditional pharmacotherapy augment behavioral modification in the treatment of nocturia?"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5572-1567","authenticated-orcid":false,"given":"Connelly D.","family":"Miller","sequence":"first","affiliation":[{"name":"Department of Urology SUNY Downstate Health Sciences University  Brooklyn New York USA"},{"name":"Department of Urology Veterans Affairs New York Harbor Healthcare System  Brooklyn New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas F.","family":"Monaghan","sequence":"additional","affiliation":[{"name":"Department of Urology SUNY Downstate Health Sciences University  Brooklyn New York USA"},{"name":"Department of Urology Veterans Affairs New York Harbor Healthcare System  Brooklyn New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis J.","family":"Robins","sequence":"additional","affiliation":[{"name":"Department of Urology SUNY Downstate Health Sciences University  Brooklyn New York USA"},{"name":"Department of Urology Veterans Affairs New York Harbor Healthcare System  Brooklyn New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey P.","family":"Weiss","sequence":"additional","affiliation":[{"name":"Department of Urology SUNY Downstate Health Sciences University  Brooklyn New York USA"},{"name":"Department of Urology Veterans Affairs New York Harbor Healthcare System  Brooklyn New York 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