{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T09:24:54Z","timestamp":1790846694056,"version":"4.1.0"},"reference-count":58,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T00:00:00Z","timestamp":1621296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the effects of psychotropic drugs on bladder function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A systematic review was carried out by searching PubMed and Embase databases for randomized controlled trials enrolling patients treated with psychotropic drugs with available information on treatment\u2010related urinary disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 52 studies was selected. In antidepressant therapy, bladder voiding symptoms, rather than storage symptoms, were more frequently observed. Pooled analysis demonstrated a higher odds ratio (OR) of voiding\u00a0 disorders in comparison with placebo (OR: 3.30; confidence interval [CI]: 1.90\u20135.72; 7856 participants; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Odds for voiding dysfunction was higher for tricyclic antidepressants and for Serotonin and Norepinephrine Reuptake Inhibitors (SNRIs) when compared to Selective Serotonin Reuptake Inhibitors (SSRIs). Treatment with antipsychotics was associated with heterogeneous urinary disorders\u00a0 including emptying and storage disorders. OR for incontinence in patients with dementia taking\u00a0 antipsychotics was higher than placebo (OR: 4.09; CI: 1.71\u20139.79, <jats:italic>p<\/jats:italic>\u2009=\u20090.002) with no difference between different atypical antipsychotics. Rate of voiding disorders was not different between conventional and atypical antipsychotics (OR: 1.64; CI: 0.79\u20133.39, <jats:italic>p<\/jats:italic>\u2009=\u20090.19), although quetiapine showed higher odds to cause voiding dysfunction than other atypical antipsychotics (OR: 2.14; CI: 1.41\u20133.26; <jats:italic>p<\/jats:italic>\u2009&gt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In patients taking tricyclic antidepressants or SNRIs, bladder voiding disorders, could be the side effects of therapy rather than symptoms of a urological disease. Patients treated with these drugs should be actively monitored for the appearance of urinary symptoms. Antipsychotic treatment is associated with various urinary side effects requiring a tailored approach.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.24695","type":"journal-article","created":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T19:36:27Z","timestamp":1621366587000},"page":"1333-1348","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Urinary side effects of psychotropic drugs: A systematic review and metanalysis"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1856-7198","authenticated-orcid":false,"given":"Margherita","family":"Trinchieri","sequence":"first","affiliation":[{"name":"Psychiatric Unit, Department of Neuroscience University of Parma  Parma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7209-9191","authenticated-orcid":false,"given":"Gianpaolo","family":"Perletti","sequence":"additional","affiliation":[{"name":"Section of Medical and Surgical Sciences, Department of Biotechnology and Life Sciences University of Insubria  Varese Italy"},{"name":"Department of Human Structure and Repair, Faculty of Medicine and Medical Sciences Ghent University  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vittorio","family":"Magri","sequence":"additional","affiliation":[{"name":"Urology Secondary Care Clinic ASST\u2010Nord  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7574-3069","authenticated-orcid":false,"given":"Konstantinos","family":"Stamatiou","sequence":"additional","affiliation":[{"name":"Department of Urology Tzaneio Hospital  Pireus Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3586-666X","authenticated-orcid":false,"given":"Emanuele","family":"Montanari","sequence":"additional","affiliation":[{"name":"Department of Urology IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico\u2014University of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9394-8292","authenticated-orcid":false,"given":"Alberto","family":"Trinchieri","sequence":"additional","affiliation":[{"name":"Department of Urology IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico\u2014University of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410x.2000.00409.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-200831050-00002"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.22851"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2020.02.013"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(17)30126-8"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-5846(02)00342-1"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0269-4727.2003.00505.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6882-4-12"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1503\/jpn.130040"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004714-198502000-00003"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40199-019-00257-4"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004714-199604000-00003"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.wnf.0000172993.89879.0f"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2010.01800.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-4943(98)80021-6"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2013-306439"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004850-199711000-00005"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610201007475"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00422420"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61081-3"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1819.2011.02243.x"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000143"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.287.14.1807"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v68n0603"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2015.413"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.148.6.718"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.57.7.649"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001168"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004850-199903000-00003"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.2006.163.4.600"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.2007.164.7.1050"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.4310"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.752"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/JGP.0b013e3181557b47"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-5846(01)00175-0"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-003-1698-1"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/papr.12409"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/hup.1158"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.164.6.802"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(98)00092-4"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0000000000000060"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002130100791"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300327"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1186\/1744-859X-11-6"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.171.6.564"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2011.06.026"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.2006.163.4.611"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02850218"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.JGP.0000196628.12010.35"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.108.061960"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-014-3485-6"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.4088\/PCC.v06n0204"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002508-199712000-00009"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2008.07.004"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2008.02.009"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2019.0828"},{"issue":"2","key":"e_1_2_8_58_1","first-page":"1014","article-title":"Effects of duloxetine, a combined serotonin and norepinephrine reuptake inhibitor, on central neural control of lower urinary tract function in the chloralose\u2010anesthetized female cat","volume":"274","author":"Thor KB","year":"1995","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.WNF.0000228174.08885.AB"}],"container-title":["Neurourology and Urodynamics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nau.24695","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/nau.24695","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nau.24695","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T16:16:22Z","timestamp":1692980182000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/nau.24695"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,18]]},"references-count":58,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["10.1002\/nau.24695"],"URL":"https:\/\/doi.org\/10.1002\/nau.24695","archive":["Portico"],"relation":{},"ISSN":["0733-2467","1520-6777"],"issn-type":[{"value":"0733-2467","type":"print"},{"value":"1520-6777","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,18]]},"assertion":[{"value":"2021-03-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}