{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T18:03:01Z","timestamp":1789236181870,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,6,15]],"date-time":"2021-06-15T00:00:00Z","timestamp":1623715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 81870523"],"award-info":[{"award-number":["No. 81870523"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To investigate the abnormalities of functional connectivity (FC) within the prefrontal cortex (PFC) of patients with interstitial cystitis\/bladder pain syndrome (IC\/BPS) based on resting state functional near\u2010infrared spectroscopy (rs\u2010fNIRS) data using FC matrix analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Ten patients with IC\/BPS (females, 9; mean age, 56.9\u2009\u00b1\u200912.432 years) and 15 age\u2010 and gender\u2010matched healthy controls (HC) (females, 12; mean age, 55.067\u2009\u00b1\u20097.46 years) participated in this rs\u2010fNIRS study. Two rs\u2010fNIRS scans were performed (when the bladder was empty and when the desire to void was strong). The Pearson's correlation coefficient between the time series of the 22 channels was calculated to obtain a 22\u2009\u00d7\u200922 FC matrix for each subject. A two\u2010sample <jats:italic>t<\/jats:italic>\u2010test (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05) was performed to compare group differences in the FC matrix between patients with IC\/BPS and HC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>FC was significantly decreased within the PFC in the IC\/BPS group based on a two\u2010sample <jats:italic>t<\/jats:italic>\u2010test (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05) compared with HC. FC decreased in a wider range of brain regions during the strong desire to void state (4 brain regions and 28 edges) when compared with the empty bladder state (3 brain regions and 18 edges).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>FC abnormalities in IC\/BPS patients may lead to frontal lobe disorders involved in processing sensory integration, motivation drive, emotional control, and decision\u2010making whether to urinate, leading to urinary control dysfunction manifested as typical clinical IC\/BPS symptoms. Our results may provide new insight into the pathogenesis of IC\/BPS and new brain biomarkers for diagnosis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.24729","type":"journal-article","created":{"date-parts":[[2021,6,15]],"date-time":"2021-06-15T22:21:01Z","timestamp":1623795661000},"page":"1634-1642","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Abnormal functional connectivity within the prefrontal cortex in interstitial cystitis\/bladder pain syndrome (IC\/BPS): A pilot study using resting state functional near\u2010infrared spectroscopy (rs\u2010fNIRS)"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9247-3264","authenticated-orcid":false,"given":"Dongqing","family":"Pang","sequence":"first","affiliation":[{"name":"School of Rehabilitation Capital Medical University  Beijing China"},{"name":"Department of Urology China Rehabilitation Research Centre  Beijing 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