{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T15:48:36Z","timestamp":1788364116180,"version":"build-2803163510"},"reference-count":15,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,8,5]],"date-time":"2021-08-05T00:00:00Z","timestamp":1628121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To determine the bleeding risk in patients taking anticoagulants (AC) and antiplatelets (AP) before onabotulinumtoxinA (BoNT\u2010A) injections and improve peri\u2010operative decision making and counseling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a retrospective review of patients having intravesical BoNT\u2010A in three teaching hospitals from January 2016 to July 2018. Demographic data, indication for intravesical BoNT\u2010A injection, and side\u2010effects of significant bleeding requiring intervention were recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Five hundred and thirty\u2010two patients had intravesical BoNT\u2010A injections during this time. Sixty\u2010three patients of mean age 69 years (range 19\u201389) had a total of 114 separate rounds of BoNT\u2010A injections whilst on treatment dose AC\/AP therapy. Of the 63, there were 33 males, with 46 having idiopatic detrusor overactivity and 17 with neurogenic detrusor overactivity. Each patient had between 1 and 7 repeat injections during the studied period. AC\/AP use across the 114 episodes included; aspirin 44, clopidogrel 37, warfarin 19, and NOAC (novel\/non\u2010vitamin K oral anticoagulant) 14. Patients on warfarin who had point of care testing all had international normalized ratio less than 3. BoNT\u2010A dose varied from 100U to 300U\u2014modal dosage was 200U.1\/114(0.88%) injection episodes resulted in postinjection hematuria requiring overnight admission. This resolved spontaneously, with an overnight catheter. This patient was on rivaroxaban and had 300U of BoNT\u2010A injected through 20 sites, on a background of previous prostate radiotherapy and self\u2010catheterization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Continuation of AP\/AC therapy during intravesical BoNT\u2010A injection treatment appears to be safe\u2014with a 0.88% rate of spontaneously resolving hematuria.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/nau.24758","type":"journal-article","created":{"date-parts":[[2021,8,5]],"date-time":"2021-08-05T04:35:31Z","timestamp":1628138131000},"page":"1829-1833","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Intravesical onabotulinumtoxinA injections in patients on antiplatelet and anticoagulation therapy"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1688-9767","authenticated-orcid":false,"given":"Elsie E.","family":"Mensah","sequence":"first","affiliation":[{"name":"Department of Urology St George's University Hospital NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1215-6585","authenticated-orcid":false,"given":"Bogdan","family":"Toia","sequence":"additional","affiliation":[{"name":"Department of Urology University College Hospital at Westmoreland Street London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5680-6570","authenticated-orcid":false,"given":"Linh","family":"Nguyen","sequence":"additional","affiliation":[{"name":"School of Medicine St George's University of London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rizwan","family":"Hamid","sequence":"additional","affiliation":[{"name":"Department of Urology University College Hospital at Westmoreland Street London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahreen","family":"Pakzad","sequence":"additional","affiliation":[{"name":"Department of Urology University College Hospital at Westmoreland Street London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1208-9826","authenticated-orcid":false,"given":"Jeremy L.","family":"Ockrim","sequence":"additional","affiliation":[{"name":"Department of Urology University College Hospital at Westmoreland Street London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"Walker","sequence":"additional","affiliation":[{"name":"Epsom and St Helier University Hospitals NHS Trust Surrey UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9074-7604","authenticated-orcid":false,"given":"Tamsin J.","family":"Greenwell","sequence":"additional","affiliation":[{"name":"Department of Urology University College Hospital at Westmoreland Street London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tharani","family":"Nitkunan","sequence":"additional","affiliation":[{"name":"Epsom and St Helier University Hospitals NHS Trust Surrey UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davendra","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Urology St George's University Hospital NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8608-2091","authenticated-orcid":false,"given":"Jai H.","family":"Seth","sequence":"additional","affiliation":[{"name":"Department of Urology St George's University Hospital NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,5]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"Hospital Episode Statistics. 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