{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T23:53:30Z","timestamp":1773359610334,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T00:00:00Z","timestamp":1631145600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Antimuscarinic drugs are the first\u2010line choice in the treatment of patients with neurogenic Detrusor Overactivity (nDO). Fesoterodine fumarate is the newest antimuscarinic drug. Limited data are published about the use of fesoterodine fumarate in patients suffering from neurogenic lower urinary tract dysfunction. Our study aims to determine the efficacy of fesoterodine fumarate on patients with nDO due to spinal cord lesion or multiple sclerosis (MS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is an open\u2010label prospective interventional study. Eligible patients were 18\u201380 years old with SCL or MS and nDO confirmed by a urodynamic study (UDS). At baseline, patients underwent a UDS to confirm nDO. Quality of life (QoL) was assessed by the Short\u2010Form (SF) Qualiveen questionnaire. Patients received fesoterodine 8\u2009mg\/day for 3 months and were re\u2010evaluated with UDS and SF\u2010Qualiveen. The primary endpoint was the confirmation of the maximum detrusor pressure (<jats:italic>P<\/jats:italic><jats:sub>detmax<\/jats:sub>) reduction after treatment. Secondary endpoints were: evaluation of maximum bladder capacity and compliance and QoL effect. Statistical analysis included Wilcoxon\u2010test using SPSSv26.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred and twenty\u2010four patients completed the study. Ninety\u2010five of them (76.6%) had SCL, while 29 (23.4%) had MS. <jats:italic>P<\/jats:italic><jats:sub>detmax<\/jats:sub>, maximum bladder capacity, and compliance had significant reduction after treatment (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) in the whole group and each subgroup. SF\u2010Qualiveen revealed a significant increase in QoL in each group (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Fesoterodine fumarate (8\u2009mg) is an efficacious drag in patients with SCL and MS, as it significantly decreases the detrusor pressure, increases the bladder capacity and compliance, and improves the QoL.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.24790","type":"journal-article","created":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T11:57:58Z","timestamp":1631188678000},"page":"2026-2033","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Efficacy of fesoterodine fumarate (8\u2009mg) in neurogenic detrusor overactivity due to spinal cord lesion or multiple sclerosis: A prospective study"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4689-6899","authenticated-orcid":false,"given":"Charalampos","family":"Konstantinidis","sequence":"first","affiliation":[{"name":"Urology and Neuro\u2010Urology Unit National Rehabilitation Center  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Samarinas","sequence":"additional","affiliation":[{"name":"Department of Urology General Hospital \u201cKoutlibanio\u201d  Larissa Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moira","family":"Tzitzika","sequence":"additional","affiliation":[{"name":"Urology and Neuro\u2010Urology Unit National Rehabilitation Center  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zisis","family":"Kratiras","sequence":"additional","affiliation":[{"name":"Urology and Neuro\u2010Urology Unit National Rehabilitation Center  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgios","family":"Panagiotakopoulos","sequence":"additional","affiliation":[{"name":"Department of General Pharmacology, School of Medicine University of Patra  Patras Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstantinos","family":"Giannitsas","sequence":"additional","affiliation":[{"name":"Department of Urology, School of Medicine University of Patra  Patras Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anastasios","family":"Athanasopoulos","sequence":"additional","affiliation":[{"name":"Department of Urology, School of Medicine University of Patra  Patras Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,9,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.23397"},{"issue":"11","key":"e_1_2_10_3_1","first-page":"S580","article-title":"Overactive bladder significantly affects quality of life","volume":"6","author":"Abrams P","year":"2000","journal-title":"Am J Manag Care"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2377-14-74"},{"key":"e_1_2_10_5_1","unstructured":"ThompsonHJ MaukKL. 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