{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T01:57:53Z","timestamp":1769824673867,"version":"3.49.0"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,9,16]],"date-time":"2021-09-16T00:00:00Z","timestamp":1631750400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004366","name":"Tabriz University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004366","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To determine the outcome of combined transobturator tape sling (TOT) and low dose intradetrusor injection of Abobotulinumtoxin\u2010A (Abobot\u2010A, Dysport\u00ae) in women with mixed urinary incontinence (MUI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This randomized, active comparator\u2010controlled, parallel\u2010group, two\u2010part clinical trial was conducted on women who had positive Valsalva leak point pressure (VLPP)\u2009+\u2009detrusor overactivity (DO), cough\u2010associated DO. In Part 1, 20 women with MUI who had a failure of medical and behavioral therapies to cure MUI, randomized in two groups receiving TOT surgery alone, or in combination with Dysport\u00ae injection (<jats:italic>n<\/jats:italic>\u2009=\u200910 in each group), and then Part 2 was initiated as a prospective open\u2010label on 40 more patients. We performed cystoscopy and injected 300\u2009U of Dysport\u00aein 20\u201330 intradetrusor injection sites in each patient.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The patient's symptoms in both groups decreased significantly after treatment. The symptoms were improved significantly in the combination therapy group according to the International Consultation on Incontinence Questionnaire\u2010overactive bladder (ICIQ\u2010OAB) questionnaire (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001), and International Consultation on Incontinence Questionnaire\u2010urinary Incontinence\u2010short form (ICIQ\u2010UI\u2010SF) (<jats:italic>p<\/jats:italic>\u2009=\u2009.041) in comparing with the TOT group. In Part 2, the mean score was 17.10 (4.75) for ICIQ\u2010UI\u2010SF and 9.22 (2.89) for ICIQ\u2010OAB before the treatment. Twelve weeks after the intervention, the median (interquartile range: IQR) of ICIQ\u2010OAB symptoms (2.0 [3.0]; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) and ICIQ\u2010UI\u2010SF decreased, too (1. 0 [2.0]; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). Considering improvement using Patient Global Impression of Improvement scale, 46 (92.0%) stated that they had significant subjective improvement of their symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Combination therapy was accompanied with a promising effect in the patients with MUI according to the results of standardized questionnaires. However, further studies with controlled arms are recommended.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.24797","type":"journal-article","created":{"date-parts":[[2021,9,16]],"date-time":"2021-09-16T20:22:45Z","timestamp":1631823765000},"page":"211-219","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Efficacy of combination therapy of mid\u2010urethral sling and low\u2010dose Abobotulinumtoxin\u2010A injection in mixed urinary incontinence"],"prefix":"10.1002","volume":"41","author":[{"given":"Sakineh","family":"Hajebrahimi","sequence":"first","affiliation":[{"name":"Research Center for Evidence\u2010Based Medicine, Iranian EBM Center: A Joanna Briggs Institute Center of Excellence, Faculty of Medicine Tabriz University of Medical Sciences Tabriz Iran"},{"name":"Department of Urology Tabriz University of Medical Sciences Tabriz 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