{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T07:33:46Z","timestamp":1785569626426,"version":"3.56.0"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,10,19]],"date-time":"2021-10-19T00:00:00Z","timestamp":1634601600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Intradetrusor injection of Onabotulinum Toxin A (BTX\u2010A) is a third\u2010line treatment for overactive bladder (OAB). Voiding dysfunction and the need for intermittent catheterization are potential complications, consequent to bladder contractility (BC) decrement.<\/jats:p><jats:p>Primary aim: to evaluate BC variation after BTX\u2010A detrusor injection in women with idiopathic OAB.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective multi\u2010institutional observational study was conducted. Medical history, bladder diary, 24\u2010h pad test, and invasive urodynamic parameters were recorded before and 4\u20136 weeks after BTX\u2010A 100U administration. BC was measured as Modified Projected Isovolumetric Pressure (PIP1), that is, maximum flow rate (Qmax)\u2009+\u2009detrusor pressure at Qmax (PdetQmax).<\/jats:p><jats:p>Continuous variables were expressed as median and interquartile range. We compared continuous variables using Wilcoxon test and proportions between two times with Fisher exact test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No changes in PIP1 were observed (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05) in 45 women enrolled between January 2018 and September 2019. Median age was 54.6\u2009years. At baseline, 91.1% had urge urinary incontinence, with 4.9\u2009\u00b1\u20092.6 daily pads used and a 24\u2010h pad test of 205.4\u2009\u00b1\u200970.8\u2009g. Baseline detrusor contractility was normal in all the patients.<\/jats:p><jats:p>Postoperatively, an improvement in the 24\u2010h pad test (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01), daily voids (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01), and nocturia (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) occurred. Urodynamics pointed out a significant reduction of detrusor overactivity rate (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) and an increase of median maximum cystometric capacity (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). No difference was observed in median Qmax (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05), PdetQmax (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05), and PVR (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05). No patient needed postoperative catheterization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The current series provides evidence that detrusor injection of botulinum toxin is an effective option for treating OAB, without causing voiding dysfunction and BC impairment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.24820","type":"journal-article","created":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T09:46:39Z","timestamp":1634809599000},"page":"306-312","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Evaluation of the effect of 100U of Onabotulinum toxin A on detrusor contractility in women with idiopathic OAB: A multicentre prospective study"],"prefix":"10.1002","volume":"41","author":[{"given":"Gaetano","family":"De Rienzo","sequence":"first","affiliation":[{"name":"Urology, Andrology, and Kidney Transplantation Unit, Department of Emergency and Organ Transplantation University of Bari \u201cAldo Moro\u201d Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8512-7726","authenticated-orcid":false,"given":"Paolo","family":"Minafra","sequence":"additional","affiliation":[{"name":"Urology Unit SS. Annunziata Hospital Taranto Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ester","family":"Iliano","sequence":"additional","affiliation":[{"name":"Andrology and Urogynecology Clinic, Santa Maria Terni Hospital University of Perugia  Terni Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0308-8824","authenticated-orcid":false,"given":"Enrico Finazzi","family":"Agr\u00f2","sequence":"additional","affiliation":[{"name":"Department of Urology Tor Vergata University Hospital Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8534-646X","authenticated-orcid":false,"given":"Maurizio","family":"Serati","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Del Ponte Hospital University of Insubria Varese Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Giamm\u00f2","sequence":"additional","affiliation":[{"name":"CTO\u2010Spinal Cord Unit, Department of Neurourology AOU Citt\u00e0 della Salute e della Scienza di Torino Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco Paolo","family":"Bianchi","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science and Human Oncology Aldo Moro University of Bari Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Costantini","sequence":"additional","affiliation":[{"name":"Andrology and Urogynecology Clinic, Santa Maria Terni Hospital University of Perugia  Terni Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasquale","family":"Ditonno","sequence":"additional","affiliation":[{"name":"Urology, Andrology, and Kidney Transplantation Unit, Department of Emergency and Organ 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