{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T16:43:47Z","timestamp":1770741827313,"version":"3.49.0"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T00:00:00Z","timestamp":1638403200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006510","name":"Duke University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006510","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Develop models to predict outcomes after intradetrusor injection of 100 or 200 units of onabotulinumtoxinA in women with non\u2010neurogenic urgency urinary incontinence (UUI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Models were developed using 307 women from two randomized trials assessing efficacy of onabotulinumtoxinA for non\u2010neurogenic UUI. Cox, linear and logistic regression models were fit using: (1) time to recurrence over 12 months, (2) change from baseline daily UUI episodes (UUIE) at 6 months, and (3) need for self\u2010catheterization over 6 months. Model discrimination of Cox and logistic regression models was calculated using c\u2010index. Mean absolute error determined accuracy of the linear model. Calibration was demonstrated using calibration curves. All models were internally validated using bootstrapping.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Median time to recurrence was 6 (interquartile range [IQR]: 2\u201312) months. Increasing age, 200\u2009units of onabotulinumtoxinA, higher body mass index (BMI) and baseline UUIE were associated with decreased time to recurrence. The c\u2010index was 0.63 (95% confidence interval [CI]: 0.59, 0.67). Median change in daily UUIE from baseline at 6 months was \u22123.5 (IQR: \u22125.0, \u22122.3). Increasing age, lower baseline UUIE, 200\u2009units of onabotulinumtoxinA, higher BMI and IIQ\u2010SF were associated with less improvement in UUIE. The mean absolute error predicting change in UUIE was accurate to 1.6 (95% CI: 1.5, 1.7) UUI episodes. The overall rate of self\u2010catheterization was 17.6% (95% CI: 13.6%\u201322.4%). Lower BMI, 200\u2009units of onabotulinumtoxinA, increased baseline postvoid residual and maximum capacity were associated with higher risk of self\u2010catheterization. The c\u2010index was 0.66 (95% CI: 0.61, 0.76). The three calculators are available at <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/riskcalc.duke.edu\">http:\/\/riskcalc.duke.edu<\/jats:ext-link>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>After external validation, these models will assist clinicians in providing more accurate estimates of expected treatment outcomes after onabotulinumtoxinA for non\u2010neurogenic UUI in women.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.24845","type":"journal-article","created":{"date-parts":[[2021,12,3]],"date-time":"2021-12-03T05:33:24Z","timestamp":1638509604000},"page":"432-447","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Predicting outcomes after intradetrusor onabotulinumtoxina for non\u2010neurogenic urgency incontinence in women"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4603-2879","authenticated-orcid":false,"given":"Whitney K.","family":"Hendrickson","sequence":"first","affiliation":[{"name":"Department of OBGYN, Division of Urogynecology Duke University Medical Center  Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gongbo","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Biostatistics &amp; Bioinformatics Duke University  Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David D.","family":"Rahn","sequence":"additional","affiliation":[{"name":"Department of OBGYN, Division of Female Pelvic Medicine and Reconstructive Surgery University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cindy L.","family":"Amundsen","sequence":"additional","affiliation":[{"name":"Department of OBGYN, Division of Urogynecology Duke University Medical Center  Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James A.","family":"Hokanson","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Medical College of Wisconsin  Milwaukee Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megan","family":"Bradley","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproductive Services, Division of Urogynecology and Pelvic Reconstructive Surgery University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ariana L.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Urology Perelman School of Medicine at the University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vivian W.","family":"Sung","sequence":"additional","affiliation":[{"name":"Department of OBGYN, Division of Urogynecology and Pelvic Reconstructive Surgery, Women and Infants Hospital Brown University  Providence Rhode Island USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony G.","family":"Visco","sequence":"additional","affiliation":[{"name":"Department of OBGYN, Division of Urogynecology Duke University Medical Center  Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheng","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Biostatistics &amp; Bioinformatics Duke University  Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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