{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:40:31Z","timestamp":1791229231168,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,2,3]],"date-time":"2022-02-03T00:00:00Z","timestamp":1643846400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>We sought to systematically review the literature on the use of botulinum toxin (BTX\u2010A) injections in the bladder to treat overactive bladder (OAB) in men.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>A systematic review was performed to identify clinical trials on efficacy and safety of BTX\u2010A injections in the detrusor for treatment of OAB in men published from inception to October 2020. Quality assessment was performed using the Cochrane Collaboration's tool for assessing risk of bias and study characteristics were extracted by two reviewers independently.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After screening 75 abstracts, 12 trials were included in the qualitative synthesis, of which 6 were conducted exclusively in men (mean age: 66.7 years). Only two were randomized controlled studies and the remaining were observational studies, mostly case series. Total number of participants in each study ranged from 28 to 146. Therapeutic response to intravesical BTX\u2010A injection was assessed differently across the studies, which used quality\u2010of\u2010life symptom questionnaires and voiding diary parameters. Urodynamics findings were reported separately for men before and after intravesical injection of BTX\u2010A in two studies only. Pooling of outcome data was possible with adverse events reported after BTX\u2010A by seven studies, which showed urinary tract infection, urinary retention, increased postvoid residual, de novo\u00a0interstitial cystitis, and hematuria rates of 29.8%, 20.0%, 37.3%, 28.3%, and 12.4%, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Limited information regarding the efficacy and safety of BTX\u2010A bladder injections for male OAB from relatively low evidence is available. Further research is needed to better understand the risk\u2010benefit profile of BTX\u2010A in the male population.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.24879","type":"journal-article","created":{"date-parts":[[2022,2,3]],"date-time":"2022-02-03T20:49:48Z","timestamp":1643921388000},"page":"710-723","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Botulinum toxin for treating overactive bladder in men: A systematic review"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9439-0577","authenticated-orcid":false,"given":"Jose C.","family":"Truzzi","sequence":"first","affiliation":[{"name":"Department of Urology Instituto de Cancer Arnaldo Vieira de Carvalho Sao Paulo Brazil"},{"name":"Urologist Medical Affairs Division Federal University of Sao Paulo Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9569-2879","authenticated-orcid":false,"given":"Marie C.","family":"Lapitan","sequence":"additional","affiliation":[{"name":"Institute of Clinical Epidemiology, National Institutes of Health University of the Philippines Manila Manila Philippines"},{"name":"Division of Urology, Department of Surgery, College of Medicine\u2010Philippine General Hospital University of the Philippines Manila Manila Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natassia C.","family":"Truzzi","sequence":"additional","affiliation":[{"name":"Universidade Nove de Julho Medical School Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5138-3177","authenticated-orcid":false,"given":"Valerio","family":"Iacovelli","sequence":"additional","affiliation":[{"name":"Urology Unit San Carlo di Nancy General Hospital\u2013GVM Care and Research Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8127-7153","authenticated-orcid":false,"given":"Marcio A.","family":"Averbeck","sequence":"additional","affiliation":[{"name":"Department of Urology Moinhos de Vento Hospital Porto Alegre Brazil"},{"name":"Urodynamics Unit Presidente Vargas Hospital Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.23897"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.2147\/RRU.S102441"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410x.2001.02228.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-016-3225-z"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2013.10.046"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2015.01.087"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1517\/14712598.2014.897322"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2016.10.109"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.f5170"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.13945"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/2046-4053-4-1"},{"key":"e_1_2_9_13_1","unstructured":"HowickJ ChalmersI&GlasziouPet al. 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