{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T22:13:44Z","timestamp":1778192024015,"version":"3.51.4"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,2,19]],"date-time":"2022-02-19T00:00:00Z","timestamp":1645228800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Mid\u2010urethral slings are the standard treatment for women with refractory stress urinary incontinence (SUI) but are at risk\u00a0of infection or erosion due to host\u2212prothesis interaction. In this proof\u2010of\u2010concept study, we aimed at evaluating umbilical vessel sling (UVS) in incontinent female rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>UVS was\u00a0extracted from human umbilical cord lining and was placed on female rats who underwent bilateral pelvic nerve injury (PNI) to reproduce SUI (Group 3, <jats:italic>N<\/jats:italic>\u2009=\u200910). Two control groups were also studied: rats with no PNI (Group 1, <jats:italic>N<\/jats:italic>\u2009=\u20094) and rats with PNI but no UVS (Group 2, <jats:italic>N<\/jats:italic>\u2009=\u200910). Micturition calendar was frequently recorded using a metabolic cage, and leak point pressure (LPP) test was performed on Day 28. After the LPP test, rats were euthanized, and bladder\/urethra were collected for histopathological analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 24 rats were included,\u00a0of whom 10 had both PNI and UVS placement. Compared with Group 2, Group 3 had increased maximal LPP but the difference did not reach significance (respectively 21.8\u2009\u00b1\u20092.1\u2009mmHg vs. 28.4\u2009\u00b1\u20094.1\u2009mmHg, <jats:italic>p<\/jats:italic>\u2009=\u20090.2). Micturition frequencies were similar between the groups. Total voided volume was higher in Group 3 at the end of the study compared with Group 2 (12.5\u2009\u00b1\u20091.1\u2009ml vs. 9.4\u2009\u00b1\u20090.6\u2009ml,\u00a0respectively, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Histopathological findings evidenced a good local tolerance and a moderate to high tissue integration of the UVS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Biological sling derived from human umbilical vessel could be safely placed with a slight improvement of LPP in a population of rats who had bilateral PNI without major modification of micturition calendar. UVS could be a promising biomaterial in the management of SUI in women. Clinical studies are needed.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.24895","type":"journal-article","created":{"date-parts":[[2022,2,19]],"date-time":"2022-02-19T09:03:57Z","timestamp":1645261437000},"page":"777-786","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Exploratory safety study of an umbilical cord derived urethral sling in bilateral pudendal nerves injury\u2010induced urinary incontinence in female rats"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6135-1005","authenticated-orcid":false,"given":"Ugo","family":"Pinar","sequence":"first","affiliation":[{"name":"Department of Urology, APHP, Academic Hospital Piti\u00e9\u2010Salp\u00eatri\u00e8re H\u00f4pital Sorbonne Universit\u00e9  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florine","family":"Grossetete","sequence":"additional","affiliation":[{"name":"Tissue Bank of France  Mions France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurence","family":"Barnouin","sequence":"additional","affiliation":[{"name":"Tissue Bank of France  Mions France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuel","family":"Chartier\u2010Kastler","sequence":"additional","affiliation":[{"name":"Department of Urology, APHP, Academic Hospital Piti\u00e9\u2010Salp\u00eatri\u00e8re H\u00f4pital Sorbonne Universit\u00e9  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,2,19]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2010.09993.x"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0043-115736"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2003.04609.x"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001920170012"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41443-019-0219-7"},{"key":"e_1_2_12_7_1","unstructured":"Professionals SO. EAU Guidelines: urinary incontinence. Uroweb. Accessed June 8 2021.https:\/\/uroweb.org\/guideline\/urinary-incontinence\/"},{"key":"e_1_2_12_8_1","unstructured":"Health C for D and R. Urogynecologic surgical mesh implants. FDA. Published October 7 2019. Accessed June 8 2021.\u00a0https:\/\/www.fda.gov\/medical-devices\/implants-and-prosthetics\/urogynecologic-surgical-mesh-implants"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.15260"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2020.12.005"},{"key":"e_1_2_12_11_1","doi-asserted-by":"crossref","unstructured":"SaraswatL RehmanH OmarMI CodyJD AlukoP GlazenerCM.Traditional suburethral sling operations for urinary incontinence in women.Cochrane Database Syst Rev.2020;1:CD001754.doi:10.1002\/14651858.CD001754.pub5","DOI":"10.1002\/14651858.CD001754.pub5"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOU.0000000000000645"},{"key":"e_1_2_12_13_1","first-page":"82","article-title":"Very long\u2010term follow\u2010up of autologous pubovaginal fascia slings in women with stress urinary incontinence","volume":"119","author":"Kim S","year":"2021","journal-title":"Int Urogynecology J"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.24813"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.13155"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/1553350612472987"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1594.2008.00598.x"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-016-3029-1"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2005.00688.x"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.teb.2020.0024"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.30339"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.3233\/CH-131728"},{"issue":"10","key":"e_1_2_12_23_1","first-page":"1290","article-title":"Minute vascular replacements","volume":"117","author":"Christie BA","year":"1982","journal-title":"Arch Surg Chic Ill 1960"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(01)01205-5"}],"container-title":["Neurourology and Urodynamics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nau.24895","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/nau.24895","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nau.24895","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T21:03:33Z","timestamp":1692997413000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/nau.24895"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,19]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["10.1002\/nau.24895"],"URL":"https:\/\/doi.org\/10.1002\/nau.24895","archive":["Portico"],"relation":{},"ISSN":["0733-2467","1520-6777"],"issn-type":[{"value":"0733-2467","type":"print"},{"value":"1520-6777","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,19]]},"assertion":[{"value":"2021-09-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}