{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T10:13:45Z","timestamp":1792059225838,"version":"4.4.0"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,3,3]],"date-time":"2022-03-03T00:00:00Z","timestamp":1646265600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction and Objective<\/jats:title><jats:p>Parkinson's disease (PD) is the second\u2010most common degenerative neurologic disease worldwide. Overactive bladder (OAB) is prevalent in this population but can be challenging to treat. Sacral neuromodulation (SNM) is an attractive option but remains understudied. We have utilized SNM in PD patients and herein describe our outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a retrospective chart review of PD patients who underwent peripheral nerve evaluation (PNE) or Stage 1 SNM from 2000 to 2020. The primary outcome was progression to a permanent implant. The impact of PD stage and preprocedural urodynamic (UDS) parameters on test\u2010phase outcome were investigated. Long\u2010term efficacy was assessed using Wilcoxon matched\u2010pairs test looking at a change in urinary symptoms (frequency, nocturia, incontinence episodes, and pad use) documented at follow\u2010up visits and further need for treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010four patients underwent test phase SNM (7 PNE and 27 Stage 1). Median follow\u2010up was 11 (interquartile range 5.8\u201329.8) months. Indications included refractory OAB (30\/34) and nonobstructive urinary retention (4\/34). Overall, 82% (28\/34) of patients proceeded to a permanent implant. 71% (5\/7) of PNEs were successful. Test\u2010phase success did not differ based on PD disease severity or UDS parameters. In patients with OAB\/urgency incontinence who progressed to the permanent implant, there was a statistically significant improvement in their urinary symptoms from baseline. Most (68%) patients were able to discontinue OAB medications post\u2010implant. The overall lead revision rate was 14% (4\/28) and 3 devices required removal.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>SNM is an efficacious treatment option for PD patients with a high percentage of patients having improvement in their urinary symptoms.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.24900","type":"journal-article","created":{"date-parts":[[2022,3,3]],"date-time":"2022-03-03T13:14:46Z","timestamp":1646313286000},"page":"955-961","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Is sacral neuromodulation effective in patients with Parkinson's disease? A retrospective review"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7983-6411","authenticated-orcid":false,"given":"Sarah","family":"Martin","sequence":"first","affiliation":[{"name":"Glickman Urological and Kidney Institute Lerner College of Medicine, Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9170-3056","authenticated-orcid":false,"given":"Jacqueline","family":"Zillioux","sequence":"additional","affiliation":[{"name":"Glickman Urological and Kidney Institute Lerner College of Medicine, Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard B.","family":"Goldman","sequence":"additional","affiliation":[{"name":"Glickman Urological and Kidney Institute Lerner College of Medicine, Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,3]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.4081\/ni.2020.8401"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.22764"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10286-017-0480-0"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2016.10.024"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2401"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/apha.12019"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2018.07.005"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000103274.38694.b1"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2019.0677"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2011.04.071"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2009.06.023"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2010.06.006"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2013.09.017"},{"key":"e_1_2_10_15_1","first-page":"2739","volume-title":"Campbell\u2010Walsh\u2010Wein Urology","author":"Heesakkers JPFA","year":"2021"},{"key":"e_1_2_10_16_1","first-page":"2461","volume-title":"Campbell\u2010Walsh\u2010Wein Urology","author":"Chai TC","year":"2021"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20213"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2020.06.063"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2012.11.073"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2007.04.016"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.24571"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(12)70152-7"},{"key":"e_1_2_10_23_1","first-page":"338","article-title":"Polypharmacy Associated with Cognitive Decline in Newly Diagnosed Parkinson's Disease: a Cross\u2010Sectional Study","volume":"9","author":"Ishii N","year":"2019","journal-title":"DEE"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.k1315"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12617"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2012.11.089"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2017.10.006"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.14617"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.24093"}],"container-title":["Neurourology and Urodynamics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nau.24900","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/nau.24900","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nau.24900","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T22:02:36Z","timestamp":1692741756000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/nau.24900"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,3]]},"references-count":28,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["10.1002\/nau.24900"],"URL":"https:\/\/doi.org\/10.1002\/nau.24900","archive":["Portico"],"relation":{},"ISSN":["0733-2467","1520-6777"],"issn-type":[{"value":"0733-2467","type":"print"},{"value":"1520-6777","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,3]]},"assertion":[{"value":"2021-12-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}