{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T15:27:35Z","timestamp":1748014055824,"version":"3.37.3"},"reference-count":14,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,4,7]],"date-time":"2022-04-07T00:00:00Z","timestamp":1649289600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To describe prescription prevalence of oral bladder pain medications among women with interstitial cystitis\/bladder pain syndrome (IC\/BPS) and to compare with current treatment guidelines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We sampled female patients with an ICD\u20109\/10 diagnosis of IC\/BPS (595.1\/N30.10) by querying active users of the Veterans Health Administration. Medical records were reviewed to determine whether patients met IC\/BPS diagnostic criteria. A cohort of women with other pelvic pain disorders was identified. Prescription prevalence of typical non\u2010narcotic oral bladder pain medications was compared between the two groups and healthy controls. Prescription prevalence was also compared before and after the diagnosis of IC\/BPS was made using Poisson regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 641 women who met criteria for IC\/BPS and 197 women with \u201cOther pelvic pain\u201d disorders. Women with IC\/BPS were prescribed a pain medication more often than those with \u201cOther pelvic pain\u201d (77% vs. 59%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). Of the women with IC\/BPS, 44% tried three or more pain medications. Of women with a diagnosis of IC\/BPS, only 67% were prescribed an American Urological Association\u2010recommended medication. Prescription prevalence increased after diagnosis for both pentosan polysulfate (10%\u201329%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001) and hydroxyzine (17%\u201340%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001), but not for amitriptyline or cimetidine. Amitriptyline was prescribed to 223 women with IC\/BPS, only 125 of which (56%) had a documented history of depression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Many women with IC\/BPS required multiple bladder prescriptions, highlighting the difficulty in finding an effective treatment for IC\/BPS. Pentosan polysulfate and hydroxyzine were preferred IC\/BPS medications. Our next step will be to analyze treatment patterns in those patients who did not receive medications.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.24923","type":"journal-article","created":{"date-parts":[[2022,4,7]],"date-time":"2022-04-07T22:33:31Z","timestamp":1649370811000},"page":"1121-1126","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Do medication prescription patterns follow guidelines in a cohort of women with interstitial cystitis\/bladder pain syndrome?"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3354-228X","authenticated-orcid":false,"given":"Lauren N.","family":"Tholemeier","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Cedars\u2010Sinai Medical Center  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Bresee","sequence":"additional","affiliation":[{"name":"Biostatistics Core at the Samuel Oschin Comprehensive Cancer Institute, Cedars\u2010Sinai Medical Center  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda M.","family":"De Hoedt","sequence":"additional","affiliation":[{"name":"Durham Veterans Affairs Health System  Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamil E.","family":"Barbour","sequence":"additional","affiliation":[{"name":"Centers for Disease Control and Prevention  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jayoung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Surgery Cedars\u2010Sinai Medical Center  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8104-6419","authenticated-orcid":false,"given":"Stephen J.","family":"Freedland","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Urology Cedars\u2010Sinai Medical Center  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3897-5941","authenticated-orcid":false,"given":"Jennifer T.","family":"Anger","sequence":"additional","affiliation":[{"name":"Department of Urology UC San Diego Medical Center  La Jolla California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,4,7]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2011.03.132"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.18553\/jmcp.2017.23.4.474"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2011.03.064"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2015.01.086"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.5489\/cuaj.3786"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.5489\/cuaj.4505"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000083020.06212.3d"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(97)00182-9"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2007.09.011"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/03007995.2019.1586401"},{"issue":"7","key":"e_1_2_10_12_1","article-title":"Interventions for treating people with symptoms of bladder pain syndrome: a network meta\u2010analysis","volume":"7","author":"Imamura M","year":"2020","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2020.08.072"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-020-04659-w"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000176741.10094.e0"}],"container-title":["Neurourology and 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