{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T12:10:34Z","timestamp":1782216634939,"version":"3.54.5"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,4,4]],"date-time":"2022-04-04T00:00:00Z","timestamp":1649030400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>We aimed to investigate the effectiveness and safety of mirabegron for adult and child patients with neurogenic lower urinary tract dysfunction (NLUTD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A comprehensive search for articles about mirabegron treatment of NLUTD patients was conducted in PubMed, EMBASE, MEDLINE, Cochrane Library, Medicine, and\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">clinicaltrials.gov<\/jats:ext-link>\n                      databases. Retrospective studies and randomized\u2010controlled studies were included if they met the inclusion criteria and were evaluated by different quality evaluation methods according to study types. Mean difference (MD) and 95% confidence intervals (CIs) were calculated using fixed\u2010effects models or random models depending on heterogeneity. Clinical and urodynamic parameters were pooled to evaluate the efficacy, and safety was measured by adverse events rate.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 10 studies with 314 participants were finally included. Four retrospective and six prospective studies containing two randomized\u2010control trials met the inclusion criteria with moderate and high evidence levels. Compared to the baseline date, the pooled results suggested that patients who underwent mirabegron treatment presented less urinary frequency (MD\u2009=\u2009\u22120.70; 95% CI: \u22121.08 to \u22120.32;\n                      <jats:italic>p\u2009<\/jats:italic>\n                      &lt;\u20090.01) and less incontinence (MD\u2009=\u2009\u22121.62; 95% CI:\u00a0\u22122.20 to \u22121.03;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01), showed conspicuous improvements in adult and child patients' urodynamic parameters, while the incidence of adverse events (10.0% on average, 0%\u201331.25%) also demonstrated the safety of mirabegron.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Mirabegron can significantly improve urodynamic parameters and quality of life in adult and child patients with NLUTD, and increase patient compliance with a smaller complication rate.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/nau.24928","type":"journal-article","created":{"date-parts":[[2022,4,4]],"date-time":"2022-04-04T08:25:25Z","timestamp":1649060725000},"page":"1056-1064","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["The efficacy and safety of mirabegron for adult and child patients with neurogenic lower urinary tract dysfunction: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"41","author":[{"given":"Chen","family":"Yuanzhuo","sequence":"first","affiliation":[{"name":"Department of Urology, Institute of Urology, West China Hospital Sichuan University Chengdu Sichuan P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Urology, Institute of Urology, West China Hospital Sichuan University Chengdu Sichuan P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhang","family":"Chi","sequence":"additional","affiliation":[{"name":"Department of Urology, Institute of Urology, West China Hospital Sichuan University Chengdu Sichuan P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Boya","sequence":"additional","affiliation":[{"name":"Department of Urology, Institute of Urology, West China Hospital Sichuan University Chengdu Sichuan P. R. 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,4,4]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000002235"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.23774"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.106.115840"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.24211"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2015.07.071"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.23566"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/sc.2015.195"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/luts.12218"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/iju.14244"},{"key":"e_1_2_11_11_1","article-title":"Updated guidance for trusted systematic reviews: a new edition of the Cochrane Handbook for Systematic Reviews of Interventions","volume":"10","author":"Cumpston M","year":"2019","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2010.07.017"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.24657"},{"key":"e_1_2_11_14_1","first-page":"187","article-title":"Real\u2010world effects of mirabegron in patients with chronic neurogenic detrusor overactivity\u2014a retrospective cohort study","volume":"12","author":"Krebs J","year":"2020","journal-title":"Res Rep Urol"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-018-2576-0"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpurol.2020.07.020"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.24604"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2007.02.009"},{"issue":"10","key":"e_1_2_11_19_1","first-page":"s191","article-title":"The epidemiology and pathophysiology of neurogenic bladder","volume":"19","author":"Ginsberg D","year":"2013","journal-title":"Am J Manag Care"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2012.02.036"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.24039"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/iju.13498"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000002239"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.12730"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41394-021-00413-6"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.22505"}],"container-title":["Neurourology and Urodynamics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nau.24928","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/nau.24928","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nau.24928","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T13:28:33Z","timestamp":1692797313000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/nau.24928"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,4]]},"references-count":25,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["10.1002\/nau.24928"],"URL":"https:\/\/doi.org\/10.1002\/nau.24928","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.741917639.793596746","asserted-by":"object"}]},"ISSN":["0733-2467","1520-6777"],"issn-type":[{"value":"0733-2467","type":"print"},{"value":"1520-6777","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,4]]},"assertion":[{"value":"2021-12-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}