{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T17:32:54Z","timestamp":1769275974983,"version":"3.49.0"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,4,28]],"date-time":"2022-04-28T00:00:00Z","timestamp":1651104000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate lower urinary tract symptoms (LUTS) in children with infantile\u2010onset Pompe disease (IOPD) who received early treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Pompe disease (PD), or glycogen storage disease II is a rare autosomal recessive lysosomal storage disease that affects multiple organ systems. To our knowledge, only one study has focused on the relationship between LUTS and incontinence in children with PD. This cross\u2010sectional study was conducted from August 2019 through March 2021 and children with IOPD, who had received early and regular enzyme replacement therapy, were enrolled. Participants or their parents completed the Dysfunctional Voiding Scoring System (DVSS) questionnaire. All children underwent uroflowmetry and postvoid residual urine measurements. Fourteen children (age, 4\u20139 years) with IOPD were enrolled.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ten patients (71.4%) had abnormal uroflow curves. In addition, results of the DVSS revealed that approximately half (42.9%) of our IOPD patients had voiding dysfunction, with urinary incontinence as the most common symptom (64.3%, 9\/14). No significant correlations were found between LUTS and uroflow curves in children with IOPD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The frequency of LUTS and lower urinary tract dysfunction noted on uroflowmetry should encourage pediatricians to actively identify IOPD patients with LUTS, regardless of the timing and frequency of their treatments, and refer them to a urologist for further evaluation and appropriate treatment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.24950","type":"journal-article","created":{"date-parts":[[2022,4,28]],"date-time":"2022-04-28T12:33:05Z","timestamp":1651149185000},"page":"1177-1184","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Prevalence of lower urinary tract symptoms in children with early\u2010treated infantile\u2010onset Pompe disease: A single\u2010centre cross\u2010sectional study"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4890-4079","authenticated-orcid":false,"given":"Yu\u2010Kuang","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Urology Taipei Veterans General Hospital Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao\u2010Ting","family":"Teng","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Taipei Veterans General Hospital Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chia\u2010Feng","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Taipei Veterans General Hospital Taipei Taiwan"},{"name":"Department of Pediatrics, College of Medicine National Yang Ming Chiao Tung University Taipei Taiwan"},{"name":"Department of Pediatrics, College of Medicine National Yang Ming University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dau\u2010Ming","family":"Niu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Taipei Veterans General Hospital Taipei Taiwan"},{"name":"Department of Pediatrics, College of Medicine National Yang Ming Chiao Tung University Taipei Taiwan"},{"name":"Department of Pediatrics, College of Medicine National Yang Ming University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William J.","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Urology Taipei Veterans General Hospital Taipei Taiwan"},{"name":"Department of Urology, College of Medicine and Shu\u2010Tien Urological Science Research Center National Yang Ming Chiao Tung University Taipei 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