{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T17:47:36Z","timestamp":1776448056437,"version":"3.51.2"},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,5,17]],"date-time":"2022-05-17T00:00:00Z","timestamp":1652745600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Sacral neuromodulation (SNM) is third\u2010line therapy approved for urge urinary incontinence (UUI) and urgency, and nonobstructive urinary retention. Multiple sclerosis (MS) patients often suffer from neurogenic lower urinary tract dysfunction (NLUTD). The utility of SNM in the MS population is limited by magnetic resonance imaging\u00a0(MRI)\u00a0incompatibility as routine MRIs to evaluate for disease progression are required. The Axonics System is the first Food and Drug Administration\u2010approved SNM device that is 1.5\/3\u2009T full\u2010body MRI\u2010conditionally safe. This study seeks to investigate the symptomatic improvement in MS patients after implantation of the Axonics System.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All MS patients who elected for Axonics SNM from December 2019 to January 2021 were included. Demographics and scores were queried for urogenital distress inventory (UDI\u20106), incontinence impact questionnaire (IIQ\u20107), and global response assessment (GRA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifteen MS patients with UUI were included. The time to follow\u2010up averaged 121 days. On UDI\u20106, 12 patients reported improvement, 1 worsening, and 2 no change. Average UDI\u20106 scores before and after implantation were 56.6 and 25.2 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). Improvements were significant for all questions under stress urinary incontinence, UUI, and voiding difficulty subcategories. On IIQ\u20107, 14 patients reported improvement and 1 reported worsening. Average IIQ\u20107 scores before and after implantation were 59.0 and 22.2 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Improvements were significant for travel, social, and emotional subcategories, but not for physical activity. The average GRA score was 6 (\u201cmoderately improved\u201d).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The majority of MS patients reported significant initial improvement in UUI and associated quality of life measures on validated questionnaires after implantation of the Axonics System. Future studies are needed to determine the long\u2010term outcomes and durability of this MRI full\u2010body conditionally\u2010safe system.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.24955","type":"journal-article","created":{"date-parts":[[2022,5,17]],"date-time":"2022-05-17T11:00:00Z","timestamp":1652785200000},"page":"1373-1379","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Initial experience using the Axonics sacral neuromodulation system in patients with multiple sclerosis"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9316-8499","authenticated-orcid":false,"given":"Annie","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Urology Stony Brook University Hospital Stony Brook New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anjali","family":"Kapur","sequence":"additional","affiliation":[{"name":"Department of Urology Stony Brook University Hospital Stony Brook New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Spencer","family":"Mossack","sequence":"additional","affiliation":[{"name":"Department of Urology Stony Brook University Hospital Stony Brook New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0008-2785","authenticated-orcid":false,"given":"Steven J.","family":"Weissbart","sequence":"additional","affiliation":[{"name":"Department of Urology Stony Brook University Hospital Stony Brook New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9430-1693","authenticated-orcid":false,"given":"Jason M.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Urology Stony Brook University Hospital Stony Brook New York 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