{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:28:21Z","timestamp":1783556901429,"version":"3.55.0"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,5,21]],"date-time":"2022-05-21T00:00:00Z","timestamp":1653091200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Interstitial <jats:italic>cystitis\/bladder pain syndrome (IC\/BPS) is an enigmatic disease that is difficult to treat<\/jats:italic>. Even among physicians, the prevalent belief is that patients do not improve over time. In this study, we retrospectively reviewed our experience and treatment results for patients diagnosed with IC\/BPS at our clinic in India over the past 20 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Three hundred and eighty\u00a0IC\/BPS patients diagnosed between January 2001 and December 2020 were included. Patients underwent cystoscopy and hydrodistension and were treated with oral drugs, intravesical instillations, and surgery as needed. From\u00a0January 2021 to June 2021, all patients were contacted by telephone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study had 380 participants, but only 231 could be contacted for analysis. Follow\u2010up averaged 6.37 years and the median was 14 years. Eighteen percent\u00a0showed no improvement, 2% showed a slight improvement on Global Response Assessment (GRA) questionnaire and were considered nonresponders (NR). Yet, 67% reported notable improvements, and 13% moderate improvements, all of which make up 80% responders (R). In 11 patients who were operated on for ileocystoplasty, 9 showed significant improvements. In addition, three patients developed Urothelial Malignancy. Pregnancy did not affect the disease in any way.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Long\u2010term results have been encouraging for IC\/BPS patients. Unfortunately, Hunner's lesions patients need a more intensive treatment regimen. Re\u2010evaluation with cystoscopy is recommended in NR. In spite of good results of surgery in our series, it is best to perform surgery only as a last resort.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.24959","type":"journal-article","created":{"date-parts":[[2022,5,22]],"date-time":"2022-05-22T06:24:28Z","timestamp":1653200668000},"page":"1390-1398","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Interstitial cystitis\/bladder pain syndrome (IC\/BPS): Single\u2010center 20 year experience and treatment results in India"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6236-3478","authenticated-orcid":false,"given":"Nagendra N.","family":"Mishra","sequence":"first","affiliation":[{"name":"Pramukh Swami Medical College Bhaikaka University Anand Gujarat India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,5,21]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)41529-1"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.20687"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.2174\/157340480902140102153720"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.24104"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urols.2013.01.005"},{"issue":"5","key":"e_1_2_8_7_1","first-page":"512","article-title":"Clinical presentation and treatment of bladder pain syndrome\/interstitial cystitis (BPS\/IC) in India","volume":"4","author":"Mishra N","year":"2015","journal-title":"Transl Androl Urol"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2003.11.021"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/iju.13978"},{"issue":"4","key":"e_1_2_8_10_1","article-title":"Intravesical tacrolimus dissolved in water is absorbed through bladder mucosa in interstitial cystitis\/bladder pain syndrome (IC\/BPS)","volume":"201","author":"Mishra N","year":"2019","journal-title":"J Urol"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/1756287218761574"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2011.03.064"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)66915-7"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-80252-x"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxins11110676"},{"issue":"4","key":"e_1_2_8_16_1","article-title":"Hunner's lesion (HL) diagnosis in initial workup of interstitial cystitis\/bladder pain syndrome (IC\/BPS) is mandatory for managing the patients","volume":"203","author":"Mishra N","year":"2020","journal-title":"J Urol"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ucl.2006.10.006"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euf.2020.02.014"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000132323.89037.73"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.22283"},{"key":"e_1_2_8_21_1","article-title":"Risk of urinary tract carcinoma among subjects with bladder pain syndrome\/interstitial cystitis: a nationwide population\u2010based study","author":"Wu MP","year":"2018","journal-title":"Biomed Res Int"}],"container-title":["Neurourology and 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