{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T01:23:26Z","timestamp":1773969806347,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,6,30]],"date-time":"2022-06-30T00:00:00Z","timestamp":1656547200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Urethral closure function is essential for urinary continence in women and decreased urethral pressure is associated with stress urinary incontinence (SUI). For decades, the effects of serotonergic drugs on central neural control of urethral closure have been investigated and discussed. Epidemiological studies suggest that the use of selective serotonin reuptake inhibitors (SSRIs), such as citalopram, is associated with SUI. However, the literature findings are conflicting. This study aimed to evaluate citalopram's effect on opening urethral pressure (OUP) in healthy women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a randomized, double\u2010blind, placebo\u2010 and active\u2010controlled\u00a0crossover study in 24 healthy women. On three\u00a0study days, which were separated by 8 days of washout, the subjects received single doses of either 40\u2009mg citalopram (and placebo<jats:sub>reboxetine<\/jats:sub>), 8\u2009mg reboxetine (and placebo<jats:sub>citalopram<\/jats:sub>), or two placebos. Study drugs were administered at a 1\u2010h\u00a0interval due to a difference in estimated time to peak plasma concentration (<jats:italic>t<\/jats:italic><jats:sub>max<\/jats:sub>). We measured OUP with urethral pressure reflectometry under both resting and squeezing conditions of the pelvic floor at estimated <jats:italic>t<\/jats:italic><jats:sub>max<\/jats:sub> for both study drugs (one timepoint).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to placebo, citalopram increased OUP by 6.6\u2009cmH<jats:sub>2<\/jats:sub>0 (95% confidence interval [CI] 0.04\u201313.1, <jats:italic>p<\/jats:italic>\u2009=\u20090.048) in resting condition. In squeezing condition, OUP increased by 7.1\u2009cmH<jats:sub>2<\/jats:sub>0 (95% CI: 1.3\u201312.9, <jats:italic>p<\/jats:italic>\u2009=\u20090.01). Reboxetine increased OUP by 30.0\u2009cmH<jats:sub>2<\/jats:sub>0 in resting condition compared to placebo (95% CI: 23.5\u201336.5, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and 27.0\u2009cmH<jats:sub>2<\/jats:sub>0 (95% CI: 21.2\u201332.8, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) in squeezing condition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Citalopram increased OUP slightly compared to placebo suggesting that SSRI treatment does not induce or aggravate SUI.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.24985","type":"journal-article","created":{"date-parts":[[2022,6,30]],"date-time":"2022-06-30T15:11:17Z","timestamp":1656601877000},"page":"1482-1488","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Effect of single doses of citalopram and reboxetine on urethral pressure: A randomized, double\u2010blind, placebo\u2010 and active\u2010controlled three\u2010period crossover study in healthy women"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5713-2707","authenticated-orcid":false,"given":"Thea","family":"Christoffersen","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacology, Bispebjerg and Frederiksberg Hospital University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2662-4519","authenticated-orcid":false,"given":"Jonatan","family":"Kornholt","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, Bispebjerg and Frederiksberg Hospital University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Troels","family":"Riis","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, Bispebjerg and Frederiksberg Hospital University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jesper","family":"Sonne","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, Bispebjerg and Frederiksberg Hospital University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4898-2256","authenticated-orcid":false,"given":"David P.","family":"Sonne","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, Bispebjerg and Frederiksberg Hospital University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen 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