{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T21:40:49Z","timestamp":1767994849940,"version":"3.49.0"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,6,22]],"date-time":"2022-06-22T00:00:00Z","timestamp":1655856000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>To evaluate the efficacy and safety of lesion fulguration in combination with cyclosporine A (CyA) as a maintenance therapy in patients with interstitial cystitis\/bladder pain syndrome (IC\/BPS) with Hunner's lesion (HL).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective observational study of refractory patients with HL treated with daily 1.5\u2009mg\/kg or less of oral CyA following lesion fulguration. Pain severity, subjective improvement, urinary symptoms, and adverse events were used to assess long\u2010term treatment efficiency and safety.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 22 patients, median follow\u2010up under CyA was 27 months. Patients reported sustained significant reduction compared to pretreatment in pain (0\/10 vs. 8\/10; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), urinary frequency per 24\u2009h (9.5 vs. 20.8; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and nocturia (2.3 vs. 7.6; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Subjective improvement rate (SIR) and patient global impression of improvement were of 90% and 1 (\u201cvery much better\u201d), respectively, including four patients who considered themselves cured (SIR: 100%). Three patients needed an additional procedure due to pain relapse. Minor increase in creatinine was observed and three patients developed or worsened their arterial hypertension. CyA dosage was decreased to 1.2\u2009mg\/kg or less for long\u2010term relief (<jats:italic>n<\/jats:italic>\u2009=\u20098), creatinine increase (<jats:italic>n<\/jats:italic>\u2009=\u20095), and neutropenia (<jats:italic>n<\/jats:italic>\u2009=\u20091) with subsequent improvement in renal function without symptom deterioration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Oral CyA seems to allow a sustained long\u2010term relief following HL fulguration by alleviating pain, decreasing urinary symptoms, and procuring great subjective improvement. The daily low dose of 1.5\u2009mg\/kg or less appears to have limited adverse events while preventing repeated procedures. Larger trials are warranted.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.24997","type":"journal-article","created":{"date-parts":[[2022,6,22]],"date-time":"2022-06-22T13:34:25Z","timestamp":1655904865000},"page":"1498-1504","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A pilot study on oral cyclosporine A in association with fulguration for the treatment of interstitial cystitis with Hunner's lesions"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7161-6871","authenticated-orcid":false,"given":"Rapha\u00eblle","family":"Bri\u00e8re","sequence":"first","affiliation":[{"name":"Department of Surgery, Faculty of Medicine Universit\u00e9 Laval  Qu\u00e9bec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fr\u00e9d\u00e9rique","family":"Bouchard","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Sciences Universit\u00e9 de Sherbrooke Sherbrooke Qu\u00e9bec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salima","family":"Ismail","sequence":"additional","affiliation":[{"name":"Department of Surgery Centre Hospitalier Universitaire de Sherbrooke and Centre de Recherche du CHUS, Division of Urology, Faculty of Medicine and Health Sciences Sherbrooke Qu\u00e9bec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annie\u2010Kim","family":"Gareau Labelle","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Centre Hospitalier de l'Universit\u00e9 Laval (CHUL), Faculty of Medicine  Qu\u00e9bec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Le\u00a0Mai","family":"Tu","sequence":"additional","affiliation":[{"name":"Department of Surgery Centre Hospitalier Universitaire de Sherbrooke and Centre de Recherche du CHUS, Division of Urology, Faculty of Medicine and Health Sciences Sherbrooke Qu\u00e9bec 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