{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:53:24Z","timestamp":1790708004681,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,9,6]],"date-time":"2022-09-06T00:00:00Z","timestamp":1662422400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Anticholinergic medications are widely used in the treatment of overactive bladder (OAB), as well as for short\u2010term treatment of bladder symptoms following a variety of urologic surgeries. Mounting evidence points to an association between anticholinergic medications and the increased risk of incident dementia. The Society for Urodynamics, Female Pelvic Medicine, and Urogenital Reconstruction (SUFU) thus convened a committee of subject experts to contextualize the current understanding of the cognitive risks of anticholinergic medications in the urologic patient population and to provide practical clinical guidance on this subject.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Statements are based on an expert literature review and the committee's opinion. The document has been reviewed and approved by the SUFU board.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Chronic use (&gt;3 months) of OAB anticholinergic medications is likely associated with an increased risk of new\u2010onset dementia. Short\u2010term (&lt;4 weeks) use of most OAB anticholinergic medications is likely safe in most individuals. Clinicians should consider potential cognitive risks in\n                      <jats:italic>all<\/jats:italic>\n                      patient populations when prescribing OAB anticholinergics for chronic use. Consideration should be given to progressing to advanced therapy (botulinum toxin or neuromodulation) earlier in the OAB treatment paradigm\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The current body of literature supports a likely small but significant increased risk of dementia with chronic exposure to OAB anticholinergic medications. Potential harms should be balanced against potential quality of life improvement with treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/nau.25037","type":"journal-article","created":{"date-parts":[[2022,9,6]],"date-time":"2022-09-06T07:39:46Z","timestamp":1662449986000},"page":"1928-1933","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["SUFU white paper on overactive bladder anticholinergic medications and dementia risk"],"prefix":"10.1002","volume":"41","author":[{"given":"Jacqueline","family":"Zillioux","sequence":"first","affiliation":[{"name":"Department of Urology University of Virginia School of Medicine Charlottesville Virginia USA"},{"name":"Glickman Urological &amp; Kidney Institute Cleveland Clinic Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7093-558X","authenticated-orcid":false,"given":"Blayne","family":"Welk","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Surgery Western University London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8437-3861","authenticated-orcid":false,"given":"Anne M.","family":"Suskind","sequence":"additional","affiliation":[{"name":"Department of Urology University of California San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. 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