{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:52:59Z","timestamp":1790707979631,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,9,13]],"date-time":"2022-09-13T00:00:00Z","timestamp":1663027200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The study aimed to assess the impact of bladder filling rate and fluid temperature during urodynamics on bladder sensations and volume of apparition of detrusor overactivity in patients with multiple sclerosis (PwMS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Consecutive PwMS assessed with a standardized urodynamic test including three consecutive cystometries (20\u2009ml\/min, 100\u2009ml\/min, and 100\u2009ml\/min with 4\u00b0C fluid (Ice water test [IWT]) between June 2020 and March 2022 were included in this retrospective study. Data collected were bladder sensation with first desire to void (FDV) and strong desire to void (SDV). The presence of detrusor overactivity (DO) and the volume of the first uninhibited detrusor contraction were recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      One hundred and fifty\u2010seven patients (mean age 47.4\u2009\u00b1\u200911.8 years, median EDSS 3 IQR[2\u20135], 73.9% of women) were included. Increased filling rate induced delayed bladder sensations (FDV 219\u2009\u00b1\u2009109\u2009ml vs. 194\u2009\u00b1\u2009100\u2009ml; SDV 349\u2009\u00b1\u2009113\u2009ml vs. 322\u2009\u00b1\u2009124\u2009ml for 100\u2009ml\/min and 20\u2009ml\/min filling rate, respectively,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Ice water increased bladder sensations with earlier reports of needs to void (FDV 163\u2009\u00b1\u200999\u2009ml vs. 218\u2009\u00b1\u2009117\u2009ml; SDV 263\u2009\u00b1\u2009104\u2009ml vs. 351\u2009\u00b1\u2009112\u2009ml respectively;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Thirty\u2010four patients had DO during both 20\u2009ml\/min and 100\u2009ml\/min fillings, without difference in the volume of apparition (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.78). Forty\u2010four patients had DO during both 100\u2009ml\/min and IWT. Detrusor overactivity appeared for a reduced volume during IWT compared with room temperature fluid perfusion (\u221268 ml [\u221295 to \u221241];\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Filling rate and fluid temperature impact bladder sensations during cystometry in PwMS. Ice water decreased the volume of the first uninhibited detrusor contraction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/nau.25042","type":"journal-article","created":{"date-parts":[[2022,9,13]],"date-time":"2022-09-13T07:54:09Z","timestamp":1663055649000},"page":"1898-1905","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Influence of urodynamic conditions on bladder sensations and detrusor activity in patients with multiple sclerosis"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9223-4925","authenticated-orcid":false,"given":"Claire","family":"Hentzen","sequence":"first","affiliation":[{"name":"GRC 01, GREEN Group of clinical REsEarch in Neurourology, AP\u2010HP, Ho\u0302pital Tenon Sorbonne University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8260-3678","authenticated-orcid":false,"given":"Camille","family":"Chesnel","sequence":"additional","affiliation":[{"name":"GRC 01, GREEN Group of clinical REsEarch in Neurourology, AP\u2010HP, Ho\u0302pital Tenon Sorbonne University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u00eblys","family":"Teng","sequence":"additional","affiliation":[{"name":"GRC 01, GREEN Group of clinical REsEarch in Neurourology, AP\u2010HP, Ho\u0302pital Tenon Sorbonne University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie","family":"Blouet","sequence":"additional","affiliation":[{"name":"GRC 01, GREEN Group of clinical REsEarch in Neurourology, AP\u2010HP, Ho\u0302pital Tenon Sorbonne University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederique","family":"Le Breton","sequence":"additional","affiliation":[{"name":"GRC 01, GREEN Group of clinical REsEarch in Neurourology, AP\u2010HP, Ho\u0302pital Tenon Sorbonne University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Lagnau","sequence":"additional","affiliation":[{"name":"GRC 01, GREEN Group of clinical REsEarch in Neurourology, AP\u2010HP, Ho\u0302pital Tenon Sorbonne University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Miget","sequence":"additional","affiliation":[{"name":"GRC 01, GREEN Group of clinical REsEarch in Neurourology, AP\u2010HP, Ho\u0302pital Tenon Sorbonne University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard","family":"Amarenco","sequence":"additional","affiliation":[{"name":"GRC 01, GREEN Group of clinical REsEarch in Neurourology, AP\u2010HP, Ho\u0302pital Tenon Sorbonne University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,13]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.23501"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.23773"},{"issue":"3","key":"e_1_2_11_4_1","first-page":"S23","article-title":"Should we be revisiting LUT basic science and clinical measurement of LUT sensation to improve patient care? 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