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Because patients with MUI have both stress and urgency urinary incontinence (SUI and UUI) episodes and current treatment guidelines currently recommend treating the predominant symptom first, this article presents standard and emerging treatments for both SUI and UUI before discussing how well these treatments meet the medical needs of patients with MUI. Standard treatments presented include noninvasive options such as lifestyle changes and pelvic floor exercises, pharmacological agents, and surgery. Treatment of all three types of urinary incontinence (UI) is usually initiated with noninvasive options, after which treatment options diverge based on UI subtype. Multiple pharmacological agents have been developed for the treatment of UUI and overactive bladder, whereas surgery remains the standard option for SUI and stress\u2010predominant MUI. The divide between UUI and SUI options seems to be propagated in emerging treatments, with most novel pharmacological agents still targeting UUI and even having SUI and stress\u2010predominant MUI as exclusion criteria for participation in clinical trials. Considering that current treatment options focus almost exclusively on treating the predominant symptom of MUI and that emerging pharmacological treatments exclude patients with stress\u2010predominant MUI during the development phase, effective treatments for MUI are lacking both in standard and emerging practice. Ideally, agents with dual mechanisms of action could provide symptom benefit for both the stress and urgency components of MUI.<\/jats:p>","DOI":"10.1002\/nau.25065","type":"journal-article","created":{"date-parts":[[2022,10,23]],"date-time":"2022-10-23T19:54:53Z","timestamp":1666554893000},"page":"401-408","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Mixed urinary incontinence: Are there effective treatments?"],"prefix":"10.1002","volume":"42","author":[{"given":"Xavier","family":"Game","sequence":"first","affiliation":[{"name":"Department of Urology CHU Rangueil Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"Dmochowski","sequence":"additional","affiliation":[{"name":"Department of Urology Vanderbilt University Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4879-6672","authenticated-orcid":false,"given":"Dudley","family":"Robinson","sequence":"additional","affiliation":[{"name":"Department of Urogynaecology Kings College Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,10,23]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2648.2010.05422.x"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1590\/1981-22562018021.180015"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)00039-X"},{"key":"e_1_2_11_5_1","first-page":"17","volume-title":"Incontinence","author":"Milsom I","year":"2016"},{"key":"e_1_2_11_6_1","first-page":"2479","volume-title":"Incontinence","author":"Wagner TH","year":"2016"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/13697137.2018.1543263"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40520-020-01712-y"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.97"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2009.04.005"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.18553\/jmcp.2014.20.2.130"},{"key":"e_1_2_11_12_1","volume-title":"EAU Guidelines on Urinary Incontinence in Adults","author":"Burkhard FC","year":"2020"},{"key":"e_1_2_11_13_1","doi-asserted-by":"crossref","unstructured":"NICE Guideline (NG123). 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