{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T01:56:35Z","timestamp":1794362195923,"version":"4.9.0"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,10,23]],"date-time":"2022-10-23T00:00:00Z","timestamp":1666483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Caffeine has long been vilified as a cause for urinary urgency incontinence (UUI) along with other potential bladder irritants such as carbonation, alcohol, and acidic juices. The objective of this study was to assess the fluid intake behavior of people with urgency, UUI, and those with lower urinary tract symptoms (LUTS) without UUI or urgency to assess if they avoided certain potential bladder irritants or had different fluid intake. We hypothesized that patients with UUI would avoid caffeine as a self\u2010management method more so than these other two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Treatment\u2010seeking men and women with LUTS in the Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN) Observational Cohort study completed a baseline 3\u2010day voiding and intake diary. \u201cComplete\u201d diaries had 3\u00a0days of data and no missing intake or voided volumes. Beverages with any caffeine, alcohol, carbonation, or acidic juice were identified and the total volume was recorded as well as the type of beverage containing caffeine to calculate the daily caffeine dose.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Four hundred and ninety\u2010one participants (277 men and 214 women) with a median age of 63 had complete diaries. Urinary urgency was more prevalent in women than men (79% vs. 55%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001) as was UUI (84% vs. 47%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). Total fluid intake over 3 days was lower among the urgency group versus the nonurgency group (median [interquartile range] 5.2 [4.0\u20136.8]\u2009L vs. 5.7 [4.3\u20137.0]\u2009L, <jats:italic>p<\/jats:italic>\u2009=\u20090.028) and the UUI group compared to the urgency without incontinence group were less likely to consume alcohol (26% vs. 37%, <jats:italic>p<\/jats:italic>\u2009=\u20090.04).<\/jats:p><jats:p>After adjusting for sex, BMI, age, and total intake volume, UUI participants had 54% lower odds of consuming any caffeine (odds ratio\u2009=\u20090.46, 95% confidence interval\u2009=\u20090.22\u20130.96, <jats:italic>p<\/jats:italic>\u2009=\u20090.04) than those without incontinence, but among those that did consume caffeine, no difference in the volume of caffeinated beverages or milligrams of caffeine consumed was detected between those with UUI and those with urgency without incontinence. No difference in carbonation or acidic juice intake was detected between groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Individuals with urgency consume a lower volume of fluid than those without urgency. UUI participants more often abstain from caffeine, but among those that consume caffeine, the dose is similar to those without UUI. One explanation for these results is that only a subset of individuals with urgency or UUI are caffeine sensitive.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.25070","type":"journal-article","created":{"date-parts":[[2022,10,23]],"date-time":"2022-10-23T19:54:37Z","timestamp":1666554877000},"page":"213-220","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Total fluid intake, caffeine, and other bladder irritant avoidance among adults having urinary urgency with and without urgency incontinence: The Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN)"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8414-3065","authenticated-orcid":false,"given":"Anne P.","family":"Cameron","sequence":"first","affiliation":[{"name":"Department of Urology University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret E.","family":"Helmuth","sequence":"additional","affiliation":[{"name":"Arbor Research Collaborative for Health Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abigail R.","family":"Smith","sequence":"additional","affiliation":[{"name":"Arbor Research Collaborative for Health Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.\u00a0Henry","family":"Lai","sequence":"additional","affiliation":[{"name":"Departments of Surgery and Anesthesiology, Division of Urologic Surgery Washington University School of Medicine  St Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cindy L.","family":"Amundsen","sequence":"additional","affiliation":[{"name":"Department of Obsterics and Gynecology Duke University Medical Center  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziya","family":"Kirkali","sequence":"additional","affiliation":[{"name":"National Institute of Diabetes and Digestive and Kidney Diseases  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenda W.","family":"Gillespie","sequence":"additional","affiliation":[{"name":"Arbor Research Collaborative for Health Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire C.","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Urology University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.\u00a0Quentin","family":"Clemens","sequence":"additional","affiliation":[{"name":"Department of Urology University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the LURN Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,10,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2017.04.097"},{"key":"e_1_2_9_3_1","unstructured":"Society of Urodynamics Female Pelvic Medicine & Urogenital Reconstruction. For Patients Overactive Bladder CCP. (sufuorg.com).\u00a0Accessed December 10 \u00a02021.\u00a0https:\/\/sufuorg.com\/resources\/patients.aspx"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2017.10.035"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.21202"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2014.02.057"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.24113"},{"key":"e_1_2_9_8_1","unstructured":"U.S. Department of Agriculture Agricultural Research Service. Food Data Central. Accessed December 1 2021.https:\/\/fdc.nal.usda.gov\/"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2018.02.3089"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000162020.10447.31"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2008.07463.x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/WON.0000000000000197"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-7796.75862"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kws411"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1089\/jwh.2016.6181"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.166.21.2381"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2042.2010.02696.x"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.113.080077"}],"container-title":["Neurourology and Urodynamics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nau.25070","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/nau.25070","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nau.25070","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T02:21:15Z","timestamp":1692584475000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/nau.25070"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,23]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1002\/nau.25070"],"URL":"https:\/\/doi.org\/10.1002\/nau.25070","archive":["Portico"],"relation":{},"ISSN":["0733-2467","1520-6777"],"issn-type":[{"value":"0733-2467","type":"print"},{"value":"1520-6777","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,23]]},"assertion":[{"value":"2022-07-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}