{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T14:23:36Z","timestamp":1793283816040,"version":"4.5.0"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,12,8]],"date-time":"2022-12-08T00:00:00Z","timestamp":1670457600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100011240","name":"Society of Urodynamics, Female Pelvic Medicine and Urogenital Reconstruction Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011240","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Overactive bladder (OAB) is often suboptimally addressed by behavioral or pharmacological treatments. Less than 15% of patients choose to pursue advanced OAB therapy (sacral nerve stimulation [SNS], percutaneous tibial nerve stimulation [PTNS], and bladder onabotulinum toxin type\u2010A\u00a0[BTX\u2010A]). We seek to better understand which factors are most important to patients when choosing a third\u2010line therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods\/Materials<\/jats:title><jats:p>We developed a conjoint analysis survey that included five attributes of the third\u2010line options for OAB (SNS, PTNS, and\u00a0BTX\u2010A). We administered the survey to new patients with urinary incontinence at two institutions. A hierarchical Bayes random effects regression analysis was used to determine the relative importance of the attributes. A choice simulator was used to model which third\u2010line treatment options patients preferred. We followed patients to see if they pursued their predicted treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 108 patients completed the study of whom 89% were women. There was representation from all age groups. The most important attributes of decision\u2010making were the frequency of future procedures, the risk of catheterization, and the need for a device. On market simulation, SNS was the preferred treatment option (47%), followed by PTNS (29%) and\u00a0BTX\u2010A (14%). Only 10% of patients did not find any treatment option acceptable.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Frequent follow\u2010up, risk of catheterization, and the need for a device were the most important attributes when making a decision on third\u2010line OAB therapy. On market simulation, SNS is the preferred treatment for all age groups though the ultimate choice in third\u2010line therapy may be affected by external factors.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.25109","type":"journal-article","created":{"date-parts":[[2022,12,8]],"date-time":"2022-12-08T16:10:15Z","timestamp":1670515815000},"page":"419-426","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Determining patient preferences in the treatment of medication\u2010refractory overactive bladder"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4328-060X","authenticated-orcid":false,"given":"Jacqueline","family":"Speed","sequence":"first","affiliation":[{"name":"Department of Urology Stanford University School of Medicine Stanford California USA"},{"name":"Department of Surgery North Shore Physicians Group Salem Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7093-558X","authenticated-orcid":false,"given":"Blayne","family":"Welk","sequence":"additional","affiliation":[{"name":"Department of Surgery St. Joseph's Hospital London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9921-601X","authenticated-orcid":false,"given":"Craig","family":"Comiter","sequence":"additional","affiliation":[{"name":"Department of Urology Stanford University School of Medicine Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1852-0018","authenticated-orcid":false,"given":"Christopher","family":"Elliott","sequence":"additional","affiliation":[{"name":"Department of Urology Santa Clara Valley Medical Center Santa Clara California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12,8]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2002.125704"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2004.10.047"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2014.11.019"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2012-002413"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000000309"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2013.10.046"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-010-1720-x"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijcp.12824"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2017.09.102"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000003320"},{"key":"e_1_2_12_12_1","volume-title":"Getting Started With Conjoint Analysis: Strategies for Product Design and Pricing Research","author":"Orme BK","year":"2019"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.2165\/11537870-000000000-00000"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.21004"},{"key":"e_1_2_12_15_1","unstructured":"Centers for Disease Control and Prevention (CDC). National Center for Health Statistics (NCHS). National Health and Nutrition Examination Survey Questionnaire (or Examination Protocol or Laboratory Protocol).Department of Health and Human Services.2018. Accessed January 7 2022.https:\/\/wwwn.cdc.gov\/nchs\/nhanes\/2015-2016\/KIQ_U_I.htm#References."},{"key":"e_1_2_12_16_1","unstructured":"Sample size issues for conjoint analysis. 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