{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T14:27:24Z","timestamp":1785940044956,"version":"3.56.0"},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,12,15]],"date-time":"2022-12-15T00:00:00Z","timestamp":1671062400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Usually, in stress urinary incontinence (SUI), nonsurgical therapy such as pelvic floor muscle training (PFMT) and lifestyle changes\u00a0are proposed before surgical treatment. Laser therapy has recently been recommended for the treatment of SUI, helping to reconstruct the collagen that supports the vagina and the pelvic floor. The aim of the study was to evaluate the efficacy of SUI treatment with a CO<jats:sub>2<\/jats:sub> intravaginal laser\u00a0in patients waiting for anti\u2010incontinence surgery (TVT\u2010O).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a prospective, case\u2013control study. Fifty\u2010two patients have been included in our study and we divided them into two groups: atrophy and\u00a0no atrophy. We also adopted a control group retrospectively identified from our database of patients undergoing PFMT. The subjective estimation of SUI symptoms before and after treatment was evaluated using the Visual Analog Scale\u00a0before and after 1, 6, and 12 months of treatment. The objective evaluation with the urodynamic study with the stress test and a 3\u2010day voiding diary\u00a0to count the number of episodes of incontinence, before and after treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The intravaginal CO<jats:sub>2<\/jats:sub> laser improved all the parameters considered for SUI in both groups. Its results were more relevant in the atrophy group, in comparison to the no atrophy group, even if they were both statistically significant. There were no statistically significant differences for all the parameters evaluated for SUI between laser treatment and PFMT in the control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The CO<jats:sub>2<\/jats:sub> laser is well\u2010tolerated, minimally invasive, safe, and showing efficacy for SUI. More studies are needed to consider it as first\u2010instance therapy, like PFMT, or at least, as a bridge therapy to surgery.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.25112","type":"journal-article","created":{"date-parts":[[2022,12,15]],"date-time":"2022-12-15T11:58:53Z","timestamp":1671105533000},"page":"393-400","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Efficacy of termoablative fractional CO<sub>2<\/sub> laser (Monnalisa Touch) in stress urinary incontinence"],"prefix":"10.1002","volume":"42","author":[{"given":"Roberto","family":"Montera","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Campus Bio\u2010Medico University Hospital Foundation Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2474-2442","authenticated-orcid":false,"given":"Fernando","family":"Ficarola","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Campus Bio\u2010Medico University Hospital Foundation Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Angioli","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Campus Bio\u2010Medico University Hospital Foundation Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corrado","family":"Terranova","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Campus Bio\u2010Medico University Hospital Foundation Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo De Cicco","family":"Nardone","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Campus Bio\u2010Medico University Hospital Foundation Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Guzzo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Campus Bio\u2010Medico University Hospital Foundation Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Plotti","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Campus Bio\u2010Medico University Hospital Foundation Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Luvero","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Campus Bio\u2010Medico University Hospital Foundation Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12,15]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pop.2019.02.004"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.22960"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22637"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurox.2019.100004"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-021-03353-7"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.23329"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/GME.0000000000000401"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-017-3437-x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2012.09.028"},{"issue":"1","key":"e_1_2_9_11_1","first-page":"67","article-title":"Minimally invasive laser procedure for early stages of stress urinary incontinence (SUI)","volume":"2012","author":"Fistonic\u0301 I","year":"2012","journal-title":"J Laser\u00a0Health Acad"},{"key":"e_1_2_9_12_1","unstructured":"RonconiL GalliM.MonaLisa Touch\u2122:The Latest Frontier in the Treatment of Vaginal Atrophy DEKA Ed. Scientific Series Vol. 2. DEKA; 2012."},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-017-3352-1"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.12137"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3109\/13697137.2015.1078668"},{"key":"e_1_2_9_16_1","unstructured":"FDA. FDA warns against use of energy\u2010based devices to perform vaginal \u201crejuvenation\u201d or vaginal cosmetic procedures: FDA safety communication.2018;1\u20104https:\/\/Www.Fda.Gov\/Medical-Devices\/Safety-Communications\/Fda-Warns-Against-Use-Energy-Based-Devices-Perform-Vaginal-Rejuvenation-or-Vaginal-Cosmetic"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/0092623X.2014.889052"}],"container-title":["Neurourology and Urodynamics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nau.25112","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/nau.25112","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nau.25112","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T10:56:07Z","timestamp":1692528967000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/nau.25112"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,15]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["10.1002\/nau.25112"],"URL":"https:\/\/doi.org\/10.1002\/nau.25112","archive":["Portico"],"relation":{},"ISSN":["0733-2467","1520-6777"],"issn-type":[{"value":"0733-2467","type":"print"},{"value":"1520-6777","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,15]]},"assertion":[{"value":"2022-07-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}