{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T02:59:50Z","timestamp":1783393190505,"version":"3.54.6"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,1,19]],"date-time":"2023-01-19T00:00:00Z","timestamp":1674086400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003122","name":"Ferring","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003122","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To explore the impact of nocturnal polyuria (NP) on health\u2010related quality of life (HRQoL), work productivity, mental health, fatigue, bother, and daytime sleepiness.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>This large\u2010scale, US population\u2010representative epidemiologic study was conducted in two parts: a web\u2010based survey and 3\u2010day bladder diary. Consenting participants completed the baseline Epidemiology of NP (EpiNP) survey online (Lower Urinary Tract Symptoms [LUTS] Tool, comorbidities, burden, and multiple HRQoL measures). Participants who reported \u22652 voids\/night, and a random sample of 100 respondents each reporting 0 or 1 void\/night, were sent urine measurement containers and asked to complete the 3\u2010day bladder diary. NP was defined as Nocturnal Polyuria Index &gt;0.33 (NPI33) or nocturnal urine production &gt;90\u2009ml\/h (NUP90). Five subgroups were created: Idiopathic NP (NP with no underlying cause), NP associated with symptoms of overactive bladder (NPOAB) or bladder outlet obstruction (NPBOO; men only), NP associated with other comorbidities (NPCOM; e.g., diabetes, hypertension, heart disease, sleep apnea), and no NP (did not meet NP criteria).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 4893 men and 5297 women completed the EpiNP survey; mean age was 54.4 (<jats:italic>SD<\/jats:italic>\u2009=\u200914.7). Significantly greater patient burden (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001) was evidenced in the nocturia group (\u22652 voids\/night) versus no nocturia group (0\u20131 void\/night) on daily impact of nocturia, LUTS Bother, prostate symptoms (men only), work productivity, physical and mental health component scores, depression, fatigue, and daytime sleepiness. NP subgroup analyses showed men in the NPBOO group and women in the NPOAB group reported the greatest impact on LUTS bother, fatigue, physical health, work productivity impairment, daytime sleepiness, and depression (women only).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This was the first large\u2010scale, epidemiologic study to explore the impact of different forms of NP on patients' HRQoL. Findings demonstrate that NP associated with other urologic or comorbid conditions appears to have greater patient burden than idiopathic NP, in particular for women.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.25126","type":"journal-article","created":{"date-parts":[[2023,1,19]],"date-time":"2023-01-19T12:23:09Z","timestamp":1674130989000},"page":"573-585","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The patient burden of nocturnal polyuria in the United States: Results from the epidemiology of nocturnal polyuria (EpiNP) study"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2960-9931","authenticated-orcid":false,"given":"Christopher R.","family":"Chapple","sequence":"first","affiliation":[{"name":"Department of Urology, Sheffield Teaching Hospitals NHS Foundation Trust University of Sheffield Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matt T.","family":"Rosenberg","sequence":"additional","affiliation":[{"name":"Department of Family Medicine Mid Michigan Health Center Jackson Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth R.","family":"Mueller","sequence":"additional","affiliation":[{"name":"Departments of Obstetrics\/Gynecology &amp; Urology, Division Female Pelvic Medicine &amp; Reconstructive Surgery Loyola University Medical Center Maywood Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0515-2578","authenticated-orcid":false,"given":"Bilal","family":"Chughtai","sequence":"additional","affiliation":[{"name":"Department of Urology Weill Cornell Medical College New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey P.","family":"Weiss","sequence":"additional","affiliation":[{"name":"Department of Urology SUNY Downstate Health Sciences University Brooklyn New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristian","family":"Juul","sequence":"additional","affiliation":[{"name":"Global Value and Access Ferring Pharmaceuticals A\/S Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne B.","family":"Brooks","sequence":"additional","affiliation":[{"name":"Patient Centered Research Former employee at Evidera Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth D.","family":"Bacci","sequence":"additional","affiliation":[{"name":"Patient Centered Research Evidera Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fredrik L.","family":"Andersson","sequence":"additional","affiliation":[{"name":"Global Value and Access Ferring Pharmaceuticals A\/S Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5773-131X","authenticated-orcid":false,"given":"Karin S.","family":"Coyne","sequence":"additional","affiliation":[{"name":"Patient Centered Research Evidera Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4833-0538","authenticated-orcid":false,"given":"JLH Ruud","family":"Bosch","sequence":"additional","affiliation":[{"name":"Department of Urology Franciscus G&amp;V Hospital Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,1,19]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.23917"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/13696998.2016.1211136"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/13696998.2020.1767631"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40273-016-0441-9"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2012.03.039"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2009.03.080"},{"key":"e_1_2_11_8_1","unstructured":"RAND EUROPE. 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