{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T01:19:42Z","timestamp":1774747182248,"version":"3.50.1"},"reference-count":41,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,1,28]],"date-time":"2023-01-28T00:00:00Z","timestamp":1674864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Interstitial cystitis\/bladder pain syndrome (IC\/BPS) has a negative impact on female sexual function. We aimed to evaluate the effect of intravesical botulinum toxin\u2010A (BTX\u2010A) injection on the improvement of sexual dysfunction and urinary symptoms using the multi\u2010domain female sexual function Index (FSFI), interstitial cystitis symptom index (ICSI), and interstitial cystitis problem index (ICPI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Method<\/jats:title><jats:p>The data of the 23 patients (study group) who received intravesical BTX\u2010A with the diagnosis of IC\/BPS were reviewed. Twenty\u2010three age\u2010matched healthy, sexually active women were determined as the control group. Patients received 100\u2009U BTX\u2010A submucosally injections, including the trigone. One hundred units of BTX\u2010A were diluted to 20\u2009cc\u00a00.9% saline, and 1 \u2009cc was then applied submucosally on 20 different points of the bladder wall (5\u2009U\/1\u2009mL per site). The study group was asked to fill out FSFI, ICSI,\u00a0and\u00a0ICPI, as well as the visual analog scale (VAS) and bladder diary before and 3 months after the treatment. Patients in the control group completed the same questionnaires once. The pre\u2010 and post\u2010treatment questionnaire scores were compared in the study group. The study group's data were also compared to the control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to the pretreatment period, the study group showed statistically significant improvement in the total FSFI score and each domain of the FSFI after BTX\u2010A injection. The mean total FSFI score and three domains of FSFI (desire, lubrication, pain) reached to the score of the control group following BTX\u2010A injection. Statistically significant improvements were also shown in scores of ICSI, ICPI, and VAS. (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>IC\/BPS is associated with a very high incidence of sexual dysfunction. Intravesical BTX\u2010A injection may provide significant improvement in sexual dysfunction in women with IC\/BPS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.25139","type":"journal-article","created":{"date-parts":[[2023,1,28]],"date-time":"2023-01-28T14:32:56Z","timestamp":1674916376000},"page":"607-614","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Sexual dysfunction in women with interstitial cystitis\/bladder pain syndrome: Do onabotulinum toxin\u2010A injections improve sexual function?"],"prefix":"10.1002","volume":"42","author":[{"given":"Murat","family":"Topcuoglu","sequence":"first","affiliation":[{"name":"Department of Urology Alaaddin Keykubat University Education and Research Hospital  Denizli Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6917-9051","authenticated-orcid":false,"given":"Murat 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