{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:52:51Z","timestamp":1790808771088,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,3,27]],"date-time":"2023-03-27T00:00:00Z","timestamp":1679875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Age\u2010related white matter hyperintensities (ARWMHs) on brain magnetic resonance imaging have been associated with lower urinary tract symptoms\/dysfunction (LUTS\/LUTD), namely overactive bladder (OAB) and detrusor overactivity. We aimed to systematically review existing data on the association between ARWMH and LUTS and which clinical tools have been used for this assessment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      We searched PubMed\/MEDLINE, Cochrane Library, and\n                      <jats:italic>clinicaltrials.gov<\/jats:italic>\n                      (from 1980 to November 2021) and considered original studies reporting data on ARWMH and LUTS\/LUTD in patients of both sexes aged 50 or above. The primary outcome was OAB. We calculated the unadjusted odds ratios (ORs) and 95% confidence intervals (95% CIs) for the outcomes of interest using random\u2010effects models.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Fourteen studies were included. LUTS assessment was heterogeneous and mainly based on the use of nonvalidated questionnaires. Urodynamics assessment was reported in five studies. ARWMHs were graded using visual scales in eight studies. Patients with moderate\u2010to\u2010severe ARWMHs were more likely to present with OAB and urgency urinary incontinence (UUI; OR\u2009=\u20091.61; 95% CI: 1.05\u20132.49,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03),\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200921.3%) when compared to patients with similar age and absent or mild ARWMH.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion and Conclusions<\/jats:title>\n                    <jats:p>High\u2010quality data on the association between ARWMH and OAB is scarce. Patients with moderate to severe ARWMH showed higher levels of OAB symptoms, including UUI, when compared to patients with absent or mild ARWMH. The use of standardized tools to assess both ARWMH and OAB in these patients should be encouraged in future research.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/nau.25174","type":"journal-article","created":{"date-parts":[[2023,3,27]],"date-time":"2023-03-27T05:05:21Z","timestamp":1679893521000},"page":"1088-1100","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Age\u2010related white matter hyperintensities and overactive bladder: A systematic review"],"prefix":"10.1002","volume":"42","author":[{"given":"Ricardo Pereira e","family":"Silva","sequence":"first","affiliation":[{"name":"Servi\u00e7o de Urologia Centro Hospitalar Universit\u00e1rio Lisboa Norte Lisboa Portugal"},{"name":"Faculdade de Medicina da Universidade de Lisboa Lisboa Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana Aguiar","family":"Sousa","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina da Universidade de Lisboa Lisboa Portugal"},{"name":"Unidade Cerebrovascular Centro Hospitalar Universit\u00e1rio Lisboa Central Lisboa Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8607-4710","authenticated-orcid":false,"given":"Filipe Abadesso","family":"Lopes","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Urologia Centro Hospitalar Universit\u00e1rio Lisboa Norte Lisboa Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Silva\u2010Ramos","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Urologia Centro Hospitalar Universit\u00e1rio do Porto Porto Portugal"},{"name":"Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar (ICBAS) Universidade do Porto Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Verdelho","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina da Universidade de Lisboa Lisboa Portugal"},{"name":"Servi\u00e7o de Neurologia Centro Hospitalar Universit\u00e1rio Lisboa Norte Lisboa Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2006.09.019"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.14271"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70124-8"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.67.5.658"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10286-013-0187-9"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.149.2.351"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2008.01832.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g7647"},{"key":"e_1_2_8_10_1","unstructured":"StroupDF BerlinJA MortonSC et al. 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