{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T11:58:45Z","timestamp":1777636725743,"version":"3.51.4"},"reference-count":12,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,6,28]],"date-time":"2023-06-28T00:00:00Z","timestamp":1687910400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Giggle incontinence (GI) is a rare form of urinary incontinence that occurs during or immediately after laughing due to involuntary and complete bladder emptying. Few studies in the literature report that methylphenidate can be effective in treatment of this condition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study is to characterize children with GI and evaluate their response to methylphenidate, as well as describe treatment duration, dosage of methylphenidate, relapse rates after discontinuation of medication, and side effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Medical records and 48\u2010h\u00a0frequency\u2010volume charts from children treated with methylphenidate for GI in the period January 2011\u2013July 2021 were retrospectively analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighteen children were diagnosed with GI and fulfilled inclusion criteria. Fifteen patients were included in analysis, as 3 out of 18 children decided not to take the methylphenidate that was prescribed. In total, 14 out of the 15 GI patients treated with methylphenidate experienced clinical effect. All patients included in the study had methylphenidate prescribed in a dose range of 5\u201320\u2009mg daily. Treatment duration ranged from 30 to 1001 days, with a median of 152 days (IQR 114, 243.5). Ten children experienced complete response and two of those reported symptom relapse after discontinuation of the methylphenidate. Only mild and short\u2010lasting side effects were reported by two patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Our study demonstrates that methylphenidate is an effective treatment in children diagnosed with GI. Side effects are mild and uncommon.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.25232","type":"journal-article","created":{"date-parts":[[2023,6,28]],"date-time":"2023-06-28T07:03:41Z","timestamp":1687935821000},"page":"1470-1475","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The effect of methylphenidate for giggle incontinence in children"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-5954-3395","authenticated-orcid":false,"given":"Ann-Kristine Mandoe","family":"Svendsen","sequence":"first","affiliation":[{"name":"Department of Pediatric and Adolescent Medicine G\u00f8dstrup Hospital Herning Denmark"},{"name":"NIDO, Centre for Research and Education G\u00f8dstrup Hospital Herning Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstantinos","family":"Kamperis","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Adolescent Medicine Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soeren","family":"Hagstroem","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Adolescent Medicine, Steno Diabetes Center North Denmark Aalborg University Hospital Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristina Nauheimer","family":"Thorsteinsson","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Adolescent Medicine Aalborg University Hospital Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mads","family":"Arvad","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Adolescent Medicine G\u00f8dstrup Hospital Herning Denmark"},{"name":"NIDO, Centre for Research and Education G\u00f8dstrup Hospital Herning Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luise","family":"Borch","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Adolescent Medicine G\u00f8dstrup Hospital Herning Denmark"},{"name":"NIDO, Centre for Research and Education G\u00f8dstrup Hospital Herning Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,6,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.22751"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2009.04.085"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)64350-9"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpurol.2021.07.015"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)65776-8"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.1995.tb00773.x"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.WON.0000341476.71685.78"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpurol.2011.12.005"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpurol.2017.04.021"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2009.03.021"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.21046"},{"key":"e_1_2_10_13_1","unstructured":"Core Team RC. 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