{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T20:30:18Z","timestamp":1776976218750,"version":"3.51.4"},"reference-count":25,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,8,2]],"date-time":"2023-08-02T00:00:00Z","timestamp":1690934400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Urinary incontinence (UI) is a common and disruptive symptom of Parkinson's disease (PD). This study aimed to identify neural correlates associated with UI among PD patients with UI (UI\u2010PD) compared to those PD patients without UI (nonUI\u2010PD) with the expectation of demonstrating increased functional connectivity (FC) between areas in the striatum and limbic system and decreased FC in executive areas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>rsfMRI and T1w data (<jats:italic>n<\/jats:italic>\u2009=\u2009119) were retrieved from the Parkinson's Progression Markers Initiative (PPMI). Resting\u2010state FC analyses assessed temporal covariance with anterior cingulate gyrus, precuneus, and putamen seed regions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The UI\u2010PD group (<jats:italic>n<\/jats:italic>\u2009=\u200932, 16 females) showed significantly greater positive FC between the bilateral putamen seed and the right caudate and right thalamus (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01), relative to individuals with PD but who did not have UI (<jats:italic>n<\/jats:italic>\u2009=\u200987, 18 females). The UI\u2010PD group showed greater negative FC between the anterior cingulate seed and right angular gyrus (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) relative to nonUI\u2010PD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Individuals with PD and UI display stronger FC within neural circuits likely affected by PD such as between the putamen and caudate, as well as within those associated with brain bladder control, compared to persons with PD and without UI. Clinical application based on this study's results can provide greater discernment of treatment strategies for UI\u2010PD patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.25258","type":"journal-article","created":{"date-parts":[[2023,8,2]],"date-time":"2023-08-02T07:41:40Z","timestamp":1690962100000},"page":"1694-1701","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Urinary incontinence\u2010related effects on functional connectivity circuits in persons with Parkinson's disease"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1783-025X","authenticated-orcid":false,"given":"Chanse","family":"Denmon","sequence":"first","affiliation":[{"name":"Center for Visual &amp; Neurocognitive Rehabilitation, Atlanta VA Medical Center Decatur Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel G.","family":"Wakeman","sequence":"additional","affiliation":[{"name":"Center for Visual &amp; Neurocognitive Rehabilitation, Atlanta VA Medical Center Decatur Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Vernon","sequence":"additional","affiliation":[{"name":"Center for Visual &amp; Neurocognitive Rehabilitation, Atlanta VA Medical Center Decatur Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keith","family":"McGregor","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences Emory University School of Medicine Atlanta Georgia USA"},{"name":"Birmingham\/Atlanta VA Geriatric Research Education and Clinical Center Birmingham Alabama USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Venkatagiri","family":"Krishnamurthy","sequence":"additional","affiliation":[{"name":"Center for Visual &amp; Neurocognitive Rehabilitation, Atlanta VA Medical Center Decatur Georgia USA"},{"name":"Department of Medicine Emory University School of Medicine Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Krishnamurthy","sequence":"additional","affiliation":[{"name":"Center for Visual &amp; Neurocognitive Rehabilitation, Atlanta VA Medical Center Decatur Georgia USA"},{"name":"Department of Physics &amp; Astronomy Georgia State University Atlanta Georgia USA"},{"name":"Department of Radiology and Imaging Sciences Emory University Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Stevens","sequence":"additional","affiliation":[{"name":"Center for Visual &amp; Neurocognitive Rehabilitation, Atlanta VA Medical Center Decatur Georgia USA"},{"name":"Department of Psychiatry and Behavioral Sciences Emory University School of Medicine Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camille P.","family":"Vaughan","sequence":"additional","affiliation":[{"name":"Center for Visual &amp; Neurocognitive Rehabilitation, Atlanta VA Medical Center Decatur Georgia USA"},{"name":"Department of Medicine Emory University School of Medicine Atlanta Georgia USA"},{"name":"Birmingham\/Atlanta VA Geriatric Research Education and Clinical Center Atlanta, Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,8,2]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.23443"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.20737"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2016.04.056"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.22767"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2019.05.019"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ca.22840"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a021691"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20867"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11884-018-0464-5"},{"key":"e_1_2_10_11_1","unstructured":"Home | Parkinson's Progression Markers Initiative. Accessed June 21 2022.https:\/\/www.ppmi-info.org\/"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.644"},{"key":"e_1_2_10_13_1","unstructured":"[dataset] Crawford. IDA\u2014Image and Data Archive. Accessed August 23 2022.https:\/\/ida.loni.usc.edu\/login.jsp"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20153"},{"key":"e_1_2_10_15_1","unstructured":"GoetzCG FahnS Martinez\u2010MartinP et al. The MDS\u2010sponsored Revision of the Unified Parkinson's Disease Rating Scale. 33. Published online:2019."},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-130341"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1089\/brain.2012.0073"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2009.06671.x"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2001.0978"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.01.021"},{"key":"e_1_2_10_21_1","unstructured":"RStudio Team.RStudio: Integrated Development for R. RStudio. PBC; 2020.http:\/\/www.rstudio.com\/"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2005.53221.x"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.08440"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/1073858412440596"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwm356"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-04492-9"}],"container-title":["Neurourology and Urodynamics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nau.25258","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,27]],"date-time":"2023-12-27T10:14:49Z","timestamp":1703672089000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/nau.25258"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,2]]},"references-count":25,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["10.1002\/nau.25258"],"URL":"https:\/\/doi.org\/10.1002\/nau.25258","archive":["Portico"],"relation":{},"ISSN":["0733-2467","1520-6777"],"issn-type":[{"value":"0733-2467","type":"print"},{"value":"1520-6777","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,2]]},"assertion":[{"value":"2023-04-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}