{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T21:10:14Z","timestamp":1771967414026,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T00:00:00Z","timestamp":1701302400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100011240","name":"Society of Urodynamics, Female Pelvic Medicine and Urogenital Reconstruction Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011240","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Onabotulinumtoxin A (BTX\u2010A) is a well\u2010established treatment for overactive bladder (OAB). The American Urological Association (AUA) 2008 Antibiotic Best Practice Statement (BPS) recommended trimethoprim\u2010sulfamethoxazole or fluoroquinolone for cystoscopy with manipulation. The aim of the study was to evaluate concordance with antibiotic best practices at the time of BTX\u2010A injection and urinary tract infection (UTI) rates based on antibiotic regimen.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Men and women undergoing first\u2010time BTX\u2010A injection for idiopathic OAB with 100 units in 2016, within the SUFU Research Network (SURN) multi\u2010institutional retrospective database were included. Patients on suppressive antibiotics were excluded. The primary outcome was concordance of periprocedural antibiotic use with the AUA 2008 BPS antimicrobials of choice for \u201ccystoscopy with manipulation.\u201d As a secondary outcome we compared the incidence of UTI among women within 30 days after BTX\u2010A administration. Each outcome was further stratified by procedure setting (office vs. operating room; OR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the cohort of 216 subjects (175 women, 41 men) undergoing BTX\u2010A, 24 different periprocedural antibiotic regimens were utilized, and 98 (45%) underwent BTX\u2010A injections in the OR setting while 118 (55%) underwent BTX\u2010A injection in the office. Antibiotics were given to 86% of patients in the OR versus 77% in office, and 8.3% of subjects received BPS concordant antibiotics in the OR versus 82% in office. UTI rates did not vary significantly among the 141 subjects who received antibiotics and had 30\u2010day follow\u2010up (8% BPS\u2010concordant vs. 16% BPS\u2010discordant, CI \u22122.4% to 19%, <jats:italic>p<\/jats:italic>\u2009=\u20090.13). A sensitivity analysis of UTI rates based on procedure setting (office vs. OR) did not demonstrate any difference in UTI rates (<jats:italic>p<\/jats:italic>\u2009=\u20090.14).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This retrospective multi\u2010institutional study demonstrates that antibiotic regimens and adherence to the 2008 AUA BPS were highly variable among providers with lower rates of BPS concordant antibiotic use in the OR setting. UTI rates at 30 days following BTX\u2010A did not vary significantly based on concordance with the BPS or procedure setting.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.25334","type":"journal-article","created":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T13:44:14Z","timestamp":1701351854000},"page":"407-414","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Antibiotic use, best practice statement adherence, and UTI rate for intradetrusor onabotulinumtoxin\u2010A injection for overactive bladder: A multi\u2010institutional collaboration from the SUFU Research Network (SURN)"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6441-7508","authenticated-orcid":false,"given":"Katherine","family":"Shapiro","sequence":"first","affiliation":[{"name":"Department of Urology New York University New York City New York 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USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Daignault\u2010Newton","sequence":"additional","affiliation":[{"name":"Department of Urology University of Michigan Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6977-5280","authenticated-orcid":false,"given":"Giulia M.","family":"Ippolito","sequence":"additional","affiliation":[{"name":"Department of Urology University of Michigan Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1128-5083","authenticated-orcid":false,"given":"Una","family":"Lee","sequence":"additional","affiliation":[{"name":"Virginia Mason Medical Center, Seattle Washington District of Columbia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arthur","family":"Mourtzinos","sequence":"additional","affiliation":[{"name":"Department of Urology, Lahey Hospital &amp; 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