{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T09:42:16Z","timestamp":1780393336315,"version":"3.54.1"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,12,18]],"date-time":"2023-12-18T00:00:00Z","timestamp":1702857600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Importance<\/jats:title><jats:p>Autologous platelet\u2010rich plasma (A\u2010PRP) injection is a novel intervention for stress urinary incontinence (SUI) in women. However, no Phase II clinical trial has compared the outcomes of A\u2010PRP injection combined with pelvic floor muscle training (PFMT) with those of PFMT alone in these women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The primary aim was to compare the efficacy of A\u2010PRP\u2009+\u2009PFMT versus PFMT alone in women with SUI. The secondary aim was to determine any adverse effects of A\u2010PRP injection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Randomized clinical trial, single\u2010blind assessment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Urogynecology clinic at a tertiary medical center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>Women with previously untreated SUI. Women in whom there was any suspicion of urgency, those with an Overactive Bladder Symptoms Score of \u22651, and those with obesity, pelvic organ prolapse, thrombocytopenia, or coagulopathy were excluded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interventions<\/jats:title><jats:p>Two injections of A\u2010PRP were administered with a 1\u2010month interval between injections in the A\u2010PRP injection + PFMT group. Both groups received PFMT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Outcomes and Measures<\/jats:title><jats:p>The primary outcome was determined using the 1\u2010h pad weight test (PWT). Secondary outcomes were measured using the Incontinence Quality of Life Questionnaire, item 11 on the International Consultation on Incontinence Questionnaire\u2010Female Lower Urinary Tract Symptoms questionnaire, Patient Global Impression of Improvement, and the percentage subjective improvement score.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Data for 60 study participants were available for analysis (A\u2010PRP\u2009+\u2009PFMT group, <jats:italic>n<\/jats:italic>\u2009=\u200931; PFMT group, <jats:italic>n<\/jats:italic>\u2009=\u200929). The 1\u2010h PWT decreased significantly in the A\u2010PRP\u2009+\u2009PFMT group but only slightly in the PFMT group at the 5\u2010month follow\u2010up. There was a statistically significant between\u2010group difference in the 1\u2010h pad weight of about 8\u2009g in favor of the A\u2010PRP\u2009+\u2009PFMT group. A statistically significant difference in symptoms of SUI measured by the questionnaires was found between the A\u2010PRP\u2009+\u2009PFMT group and the PFMT group at the 2\u2010\u00a0and 5\u2010month follow\u2010up assessments. There were no reports of adverse events following injection of A\u2010PRP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Relevance<\/jats:title><jats:p>A\u2010PRP\u2009+\u2009PFMT could be a treatment option for women with SUI. Large Phase III randomized controlled trials are required to confirm our findings.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.25365","type":"journal-article","created":{"date-parts":[[2023,12,18]],"date-time":"2023-12-18T11:09:44Z","timestamp":1702897784000},"page":"342-353","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Autologous platelet rich plasma (A\u2010PRP) combined with pelvic floor muscle training for the treatment of female stress urinary incontinence (SUI): A randomized control clinical trial"],"prefix":"10.1002","volume":"43","author":[{"given":"Apisith","family":"Saraluck","sequence":"first","affiliation":[{"name":"Department of Obstetrics &amp; Gynaecology, Faculty of Medicine Ramathibodi Hospital Mahidol University Bangkok 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