{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T13:00:12Z","timestamp":1786194012805,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T00:00:00Z","timestamp":1706572800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>While detrusor overactivity (DO) with detrusor underactivity (DU) (DO\u2010DU) has been described as typical of aging, the pathogenesis of DO\u2010DU is highly multifactorial, and often thought to involve medical conditions beyond the urinary tract. We aimed to explore potential associations between idiopathic DO\u2010DU and frailty in older women after accounting for age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The design of the study is a cross\u2010sectional single\u2010center study, in an outpatient urodynamic unit specializing in geriatrics. Participants are consecutive female patients aged \u226565 years without contributory neurological conditions or bladder outlet obstruction who completed a comprehensive geriatric assessment followed by urodynamic evaluation from 2015 to 2019. Participants were categorized as having DO, DU, combined DO\u2010DU, or a negative study. Multinomial logistic regression analysis was used to assess the relationship between urodynamic outcomes and frailty, as quantified using the Frailty index (FI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ninety\u2010five patients were included (median age 78 [interquartile range: 70\u201383] years), among whom 29% had combined DO\u2010DU. The median FI score was 0.27 (0.2\u20130.32) (5\u201312). A higher FI was associated with significantly greater age\u2010adjusted odds of DO\u2010DU when either DU or subjects with a negative urodynamic assessment were used as the reference group. Age was not significantly associated with DO\u2010DU across all multivariable analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A higher FI was associated with an increased likelihood of DO\u2010DU, which could not be attributed to the effect of age alone. The pathogenesis of DO\u2010DU is likely more complex than chronological aging in and of itself and merits further study.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.25381","type":"journal-article","created":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T15:37:56Z","timestamp":1706629076000},"page":"1075-1082","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Association between frailty and detrusor overactivity with detrusor underactivity in older women"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4220-754X","authenticated-orcid":false,"given":"Ong Damien","family":"Ly","sequence":"first","affiliation":[{"name":"GRC 001 GREEN Neuro\u2010Urology Research Group Sorbonne Universite\u0301, Rothschild Academic Hospital, AP\u2010HP Paris 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