{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T21:44:21Z","timestamp":1775166261103,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T00:00:00Z","timestamp":1705276800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To examine central sensitization (CS), and to investigate the relationship between CS, and urinary symptom severity, and quality of life (QoL) in women with overactive bladder (OAB).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A total of 144 women with OAB included the study. CS with the Central Sensitization Inventory (CSI), urinary symptom with the Overactive Bladder Questionnaire\u2010Version 8 (OAB\u2010V8), bladder diary and Patients' Perception of Intensity of Urgency Scale (PPIUS) and QoL with the King's Health Questionnaire (KHQ) were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>It was found that 47.9% (<jats:italic>n<\/jats:italic>\u2009=\u200969) of women with OAB had CS. It was observed that the CSI score was related to the OAB\u2010V8 score (<jats:italic>\u03c1<\/jats:italic>\u2009=\u20090.327; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and the average number of voids\/day (<jats:italic>\u03c1<\/jats:italic>\u2009=\u20090.291; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Additionally, urgency severity was higher in women with OAB with CS than in women with OAB without CS (<jats:italic>p<\/jats:italic>\u2009=\u20090.006). There was a relationship between the CSI score and KHQ\u2010incontinence impact (<jats:italic>\u03c1<\/jats:italic>\u2009=\u20090.250; <jats:italic>p<\/jats:italic>\u2009=\u20090.012), KHQ\u2010personal relationship (<jats:italic>\u03c1<\/jats:italic>\u2009=\u20090.253; <jats:italic>p<\/jats:italic>\u2009=\u20090.002), KHQ\u2010sleep\/energy (<jats:italic>\u03c1<\/jats:italic>\u2009=\u20090.180; <jats:italic>p<\/jats:italic>\u2009=\u20090.031), KHQ\u2010emotional state (<jats:italic>\u03c1<\/jats:italic>\u2009=\u20090.310; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and KHQ\u2010severity measurement scores (<jats:italic>\u03c1<\/jats:italic>\u2009=\u20090.391; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this study, it was observed that the majority of women with OAB had CS. It was found that more severe symptoms of CS were associated with worse urinary symptom severity and QoL in these patients. It may be beneficial to evaluate CS in the management of OAB and to consider CS when determining treatment strategies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.25394","type":"journal-article","created":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T08:09:30Z","timestamp":1705306170000},"page":"620-627","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Black box in overactive bladder: Central sensitization and its relationship with urinary symptom severity and quality of life"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6720-4452","authenticated-orcid":false,"given":"Seyda T.","family":"Celenay","sequence":"first","affiliation":[{"name":"Department of Physiotherapy and Rehabilitation, Faculty of Health Sciences Ankara Yildirim Beyazit University Ankara 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