{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T03:43:36Z","timestamp":1773027816276,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006639","name":"Grant Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006639","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Statins are widely used to treat dyslipidemia and have been shown to reduce the risk of ischemic heart disease and cerebrovascular disease. The effects of statins on ischemia\u2010induced overactive bladder (OAB) and the associated mechanisms were investigated in a rat model of chronic pelvic ischemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A pelvic ischemia model was created by iliac arterial injury (AI) and a high\u2010fat diet using male Sprague\u2212Dawley rats. Rats were assigned to 3 groups: control group, AI group, and AI\u2009+\u2009statin group. The control group underwent sham operation and was fed a normal diet. The AI group underwent AI surgery and was fed a high\u2010cholesterol diet. The AI\u2009+\u2009statin group was administered a statin for 4 weeks. Cystometry was performed for 8 weeks after surgery. Blood flow was evaluated by laser meter. Thickness of the iliac arteries was measured, and microvascular density in the lamina propria was evaluated by immunostaining for CD31. Expressions of inflammatory cytokines in the bladder were measured by real\u2010time PCR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Cystometry showed a significantly shorter voiding interval and lower bladder capacity in the AI group than in the control group. The AI\u2009+\u2009statin group showed improvement of these findings. The AI group showed decreased bladder blood flow, increased iliac arterial wall thickening, and decreased microvascular density compared to the control group. Statin administration improved blood flow. Iliac arterial wall thickening was suppressed, and microvascular density was increased by statin administration, though not significantly. Real\u2010time PCR showed significantly higher expressions of inflammatory cytokines (IL\u20106, IL\u20108, and TNF\u2010\u03b1) in the AI group than in the control group, and IL\u20106 and IL\u20108 expressions were lower in the AI\u2009+\u2009statin group than in the AI group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The present results suggest that statins are effective in OAB caused by arteriosclerosis and ischemia. The mechanism of their effects involves improved bladder blood flow and decreased bladder inflammation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.25433","type":"journal-article","created":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T13:53:05Z","timestamp":1709301185000},"page":"991-1002","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Statin administration ameliorates ischemia\u2010induced overactive bladder with improvement of blood flow and anti\u2010inflammatory effects in rats"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-8427-406X","authenticated-orcid":false,"given":"Yuichi","family":"Ishizuka","sequence":"first","affiliation":[{"name":"Department of Urology Tohoku University Graduate School of Medicine Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3961-1004","authenticated-orcid":false,"given":"Yohei","family":"Satake","sequence":"additional","affiliation":[{"name":"Department of Urology Tohoku University Graduate School of Medicine Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2164-3091","authenticated-orcid":false,"given":"Shingo","family":"Kimura","sequence":"additional","affiliation":[{"name":"Department of Urology Tohoku University Graduate School of Medicine Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3092-7715","authenticated-orcid":false,"given":"Shinichi","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Department of Urology Tohoku University Graduate School of Medicine Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6175-3063","authenticated-orcid":false,"given":"Naoki","family":"Kawamorita","sequence":"additional","affiliation":[{"name":"Department of Urology Tohoku University Graduate School of Medicine Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7224-1100","authenticated-orcid":false,"given":"Akihiro","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Urology Tohoku University Graduate School of Medicine Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,3]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.23897"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ogc.2015.10.002"},{"issue":"3","key":"e_1_2_11_4_1","first-page":"S16","article-title":"Are oxidative stress and ischemia significant causes of bladder damage leading to lower urinary tract dysfunction? 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