{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T06:20:07Z","timestamp":1789539607094,"version":"build-2803163510"},"reference-count":59,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T00:00:00Z","timestamp":1710806400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the burden and identify correlates of female sexual dysfunction (FSD) among women with prediabetes (PreD) and type 2 diabetes (T2D) enrolled in the Diabetes Prevention Program (DPP) Outcomes Study (DPPOS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The DPPOS visit included the Female Sexual Function Index (FSFI) to determine sexual function. Of 1464 participants, 1320 (90%) completed the (FSFI) and 426 were sexually active. A backward selection multivariable logistic regression model estimated the odds of FSD for sociodemographic, clinical, and diabetes\u2010related covariates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred and eighty\u2010five\u00a0(43%) had a score of \u226426.55 and met the criteria for FSD. After adjustment for DPP treatment and age, urinary incontinence (UI) (odds ratio [OR]\u2009=\u20091.91, 95% confidence interval [CI]\u2009=\u20091.15\u20133.17) and hysterectomy (OR\u2009=\u20091.89, 95%\u00a0CI\u2009=\u20091.01\u20133.53) were associated with increased odds of FSD. Increased body mass index was protective for FSD (OR\u2009=\u20090.93 per kg\/m<jats:sup>2<\/jats:sup>, 95%\u00a0CI\u2009=\u20090.89\u20130.96). Michigan Neuropathy Screening Instrument\u2010based peripheral neuropathy (mean\u00b1SD scores 1.1\u00b11.3 vs. 0.9\u00b11.1, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001) and Electrocardiogram (ECG)\u2010based autonomic dysfunction measures (mean\u2009\u00b1\u2009SD heart rate levels 64.3\u2009\u00b1\u20096.8 vs. 65.6\u2009\u00b1\u200910.2, <jats:italic>p<\/jats:italic>\u2009=\u20090.008) were associated with FSD. There were no differences in diabetes rates between women who did (66.5%) and did not (66%) have (<jats:italic>p<\/jats:italic>\u2009=\u20090.7).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>FSD is prevalent in women with PreD and T2D. Our findings suggest that FSD is associated with neuropathic complications commonly observed in PreD and T2D.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.25436","type":"journal-article","created":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T10:16:08Z","timestamp":1710843368000},"page":"977-990","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Prevalence and predictors of female sexual dysfunction among sexually active women in the diabetes prevention program outcomes study"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9528-3191","authenticated-orcid":false,"given":"Priyanka","family":"Gupta","sequence":"first","affiliation":[{"name":"Department of Urology University of Michigan Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay","family":"Doherty","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Bioinformatics, Biostatistics Center, Milken Institute School of Public Health George Washington University Washington District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marinella","family":"Temprosa","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Bioinformatics, Biostatistics Center, Milken Institute School of Public Health George Washington University Washington District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodica","family":"Pop\u2010Busui","sequence":"additional","affiliation":[{"name":"Division of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine University of Michigan Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kishore M.","family":"Gadde","sequence":"additional","affiliation":[{"name":"Department of Surgery University of California Irvine Orange California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prachi","family":"Singh","sequence":"additional","affiliation":[{"name":"Pennington Biomedical Research Center Louisiana State University System Baton Rouge Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur H.","family":"Owora","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics Indiana University School of Public Health Bloomington Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hunter","family":"Wessells","sequence":"additional","affiliation":[{"name":"Department of Urology and Diabetes, Research Center University of Washington School of Medicine Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3420-8021","authenticated-orcid":false,"given":"Aruna V.","family":"Sarma","sequence":"additional","affiliation":[{"name":"Department of Urology University of Michigan Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the Diabetes Prevention Program Research Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2004.10107.x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9136(199810)15:10<809::AID-DIA689>3.0.CO;2-Z"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.25.4.672"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc08-1164"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.281.6.537"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.22.4.623"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.23.11.1619"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa012512"},{"issue":"9702","key":"e_1_2_10_10_1","first-page":"1677","article-title":"10\u2010year follow\u2010up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study [Erratum appears in Lancet. 2009 Dec 19;374(9707):2054]","volume":"374","author":"The Diabetes Prevention Program Research Group","year":"2009","journal-title":"Lancet"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/009262300278597"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc05-2463"},{"key":"e_1_2_10_13_1","doi-asserted-by":"crossref","unstructured":"BeckAT SteerRA BrownG. 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