{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T13:28:57Z","timestamp":1791898137573,"version":"4.3.4"},"reference-count":24,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,5,8]],"date-time":"2024-05-08T00:00:00Z","timestamp":1715126400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Vibegron is a selective \u03b2<jats:sub>3<\/jats:sub>\u2010adrenergic receptor agonist that was approved by the US Food and Drug Administration in December 2020 for the treatment of overactive bladder in adults. This retrospective study assessed US pharmacy claims data to evaluate the real\u2010world adherence and persistence of vibegron compared with mirabegron and with anticholinergics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>This analysis used the Optum Research Database to identify adults with \u22651 pharmacy claim for vibegron, mirabegron, or an anticholinergic from April 1, 2021, to August 31, 2022. Patients had \u2265\u200990 days of continuous commercial or Medicare medical and pharmacy coverage preindex and \u2265\u200960 days of continuous pharmacy coverage postindex. Two independent propensity\u2010score models matched patients treated with (1) vibegron versus mirabegron and (2) vibegron versus anticholinergics on key variables such as demographics and clinical characteristics, index copay, days' supply, and time of entry into analysis (index quarter). Adherence was measured by proportion of days covered (PDC) from index to the end of follow\u2010up and was defined as PDC\u2009\u2265\u200980%. Persistence was defined as days to discontinuation of index medication (first 30\u2010day gap) or end of follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The matched vibegron and mirabegron cohorts included 4921 and 9842 patients, respectively, and the matched vibegron and anticholinergic cohorts included 4676 and 9352 patients, respectively. Patients receiving vibegron had greater mean PDC versus patients receiving mirabegron (0.67 vs. 0.64, respectively; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) or anticholinergics (0.67 vs. 0.58; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). A greater percentage of patients receiving vibegron were adherent versus those receiving mirabegron (49.0% vs. 45.1%, respectively; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) or anticholinergics (49.1% vs. 38.5%; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Persistence was longer with vibegron compared with both mirabegron (median [95% CI], 171 [159\u2013182] vs. 128 [122\u2013137] days, respectively; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and anticholinergics (172 [159\u2013183] vs. 91 [91] days; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this retrospective analysis of pharmacy claims data, patients receiving vibegron exhibited significantly higher adherence and demonstrated longer persistence in comparison to matched patient cohorts receiving either mirabegron or anticholinergics.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.25478","type":"journal-article","created":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T06:19:33Z","timestamp":1715235573000},"page":"1504-1513","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Comparative analysis of real\u2010world adherence and persistence patterns with vibegron, mirabegron, and anticholinergics in patients with overactive bladder: A retrospective claims study"],"prefix":"10.1002","volume":"43","author":[{"given":"Benjamin","family":"Chastek","sequence":"first","affiliation":[{"name":"Optum Eden Prairie Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6588-7468","authenticated-orcid":false,"given":"Adam","family":"Carrera","sequence":"additional","affiliation":[{"name":"Sumitomo Pharma America, Inc. (formerly Urovant Sciences, Inc.) Marlborough Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1246-1635","authenticated-orcid":false,"given":"Christina","family":"Landis","sequence":"additional","affiliation":[{"name":"Optum Eden Prairie Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Snyder","sequence":"additional","affiliation":[{"name":"Sumitomo Pharma America, Inc. (formerly Urovant Sciences, Inc.) Marlborough Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7568-2787","authenticated-orcid":false,"given":"Laleh","family":"Abedinzadeh","sequence":"additional","affiliation":[{"name":"Sumitomo Pharma America, Inc. (formerly Urovant Sciences, Inc.) Marlborough Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4998-582X","authenticated-orcid":false,"given":"Tim","family":"Bancroft","sequence":"additional","affiliation":[{"name":"Optum Eden Prairie Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Nesheim","sequence":"additional","affiliation":[{"name":"Sumitomo Pharma America, Inc. (formerly Urovant Sciences, Inc.) Marlborough Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7044-506X","authenticated-orcid":false,"given":"Michael","family":"Kennelly","sequence":"additional","affiliation":[{"name":"Carolinas Medical Center Charlotte North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Staskin","sequence":"additional","affiliation":[{"name":"Tufts University School of Medicine Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410x.2001.02228.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"crossref","unstructured":"GormleyEA LightnerDJ BurgioKL et al.Diagnosis and treatment of overactive bladder (non\u2010neurogenic) in adults: AUA\/SUFU guideline. 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Mirabegron interferes with the central sensitization induced by the mice model of overactive bladder","volume":"41","author":"Kwon J","year":"2022","journal-title":"Neurourol Urodyn"},{"key":"e_1_2_9_17_1","unstructured":"SumitomoPharmaAmerica Inc. GEMTESA\u00ae (vibegron). 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