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The ureteral strips were subjected to cumulative mirabegron concentrations (10<jats:sup>\u22129<\/jats:sup>\u201310<jats:sup>\u22124.5<\/jats:sup>\u2009M). Effects on frequency or amplitude of spontaneous, 10\u2009mM KCl\u2010 or EFS\u2010induced contractions were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mirabegron decreased the frequency of spontaneous ureteric contraction in a concentration\u2010dependent manner. Statistically significant decrease in the frequency of spontaneous contraction was observed at 10<jats:sup>\u22128<\/jats:sup>\u201310<jats:sup>\u22124.5<\/jats:sup>\u2009M. In 10\u2009mM KCl medium, statistically significant change in frequency was observed at 10<jats:sup>\u22129<\/jats:sup>\u201310<jats:sup>\u22124.5<\/jats:sup>\u2009M. Statistically significant decrease in the amplitudes of spontaneous contraction was observed at 10<jats:sup>\u22127<\/jats:sup>\u201310<jats:sup>\u22124.5<\/jats:sup>\u2009M. In a 10\u2009mM KCl medium, statistically significant change in amplitudes was observed at 10<jats:sup>\u22128<\/jats:sup>\u201310<jats:sup>\u22124.5<\/jats:sup>\u2009M.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Mirabegron reduced the amplitude and frequency of human ureter activity in in vitro organ bath studies. This effect was achieved in a dose\u2010dependent manner on isolated tissue strips. Although monotherapy with mirabegron remains uncertain, this study has the potential to elucidate the mechanism underlying the effectiveness of mirabegron, particularly in combination therapy for ureteral stones.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.25483","type":"journal-article","created":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T09:54:33Z","timestamp":1714038873000},"page":"1709-1717","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["In vitro effects of \u03b23\u2010adrenoceptor agonist mirabegron on the human ureter"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8470-8246","authenticated-orcid":false,"given":"Meylis","family":"Artykov","sequence":"first","affiliation":[{"name":"Department of Urology Hacettepe University Faculty of Medicine Ankara 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