{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:51:43Z","timestamp":1786978303977,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T00:00:00Z","timestamp":1716422400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Fecal incontinence, constipation, and pelvic pain are common pelvic floor symptoms (PFS), and frequently coexist with lower urinary tract symptoms (LUTS). However, their association with the longitudinal trajectory of LUTS have not been well described. Our objective was to investigate the association between PFS and the course of LUTS in community\u2010dwelling men and women.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Men and women aged \u226516 years were invited to participate in a prospective observational cohort study. At baseline, and after 12 and 24 months, participants filled in the International Consultation on Incontinence Modular Questionnaire (ICIQ\u2010MLUTS and ICIQ\u2010FLUTS) for men and women respectively, the Wexner incontinence and constipation scale, and a questionnaire on pelvic pain. Generalized estimating equations were used to examine the association between change scores in defecation problems and pelvic pain, and LUTS change scores.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 694 men and 997 women gave informed consent, with 417 men and 566 women included in the analysis. The mean age was 63.2\u2009\u00b1\u200912.7 years for men and 58.6\u2009\u00b1\u200914.8 years for women. The study showed minor changes in LUTS scores over the 0\u201312 and 12\u201324\u2010month periods. Generalized estimating equations revealed positive associations between changes in constipation and fecal incontinence and LUTS changes in both sexes. For instance, a one\u2010point increase in Wexner constipation score was associated with 0.376 (0.165, 0.587) points higher LUTS change in men and 0.223 (0.109, 0.336) points in women during the 0\u201312\u2010month follow\u2010up. However, associations between changes in pain and LUTS scores varied across sexes and time periods.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We observed minor changes in LUTS over time and weak associations between PFS and LUTS that sometimes differed between males and females, emphasizing the need for sex\u2010specific considerations. These insights can provide valuable guidance for the development of targeted prevention trials, ultimately aiming to enhance overall pelvic health and patient well\u2010being.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/nau.25492","type":"journal-article","created":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T06:38:35Z","timestamp":1716446315000},"page":"1566-1573","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["The association of fecal incontinence, constipation, and pelvic pain with the course of lower urinary tract symptoms in community\u2010dwelling men and women"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1156-1519","authenticated-orcid":false,"given":"Dina M.","family":"Mahjoob","sequence":"first","affiliation":[{"name":"Department of Urology, School for Mental Health and Neuroscience, Faculty of Health, Medicine and Life Sciences Maastricht University Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7833-5260","authenticated-orcid":false,"given":"Grietje E.","family":"Knol\u2010de Vries","sequence":"additional","affiliation":[{"name":"Department of Primary and Long\u2010term Care University of Groningen, University Medical Center Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9240-0199","authenticated-orcid":false,"given":"Michiel","family":"de Boer","sequence":"additional","affiliation":[{"name":"Department of Primary and Long\u2010term Care University of Groningen, University Medical Center Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2328-8265","authenticated-orcid":false,"given":"Gommert A.","family":"van Koeveringe","sequence":"additional","affiliation":[{"name":"Department of Urology, School for Mental Health and Neuroscience, Faculty of Health, Medicine and Life Sciences Maastricht University Maastricht The Netherlands"},{"name":"Department of Urology Maastricht University Medical Centre Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1086-8730","authenticated-orcid":false,"given":"Marco H.","family":"Blanker","sequence":"additional","affiliation":[{"name":"Department of Primary and Long\u2010term Care University of Groningen, University Medical Center Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,23]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2006.09.019"},{"key":"e_1_2_11_2_2","unstructured":"discussion1314\u20101315."},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2008.07601.x"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.300.11.1311"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cont.2022.100028"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2001.114868"},{"key":"e_1_2_11_6_2","unstructured":"discussion1501\u20101503."},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000000057"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2022.06.020"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2010.01.026"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2010.03.014"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2011.10866.x"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2013.10.003"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1089\/jwh.2020.8624"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/01443610500231435"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.25020"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)66926-1"},{"key":"e_1_2_11_17_1","unstructured":"ICIQ\u2010MLUTS ICIQ [Internet]. 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