{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T07:20:37Z","timestamp":1789024837317,"version":"build-2803163510"},"reference-count":27,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T00:00:00Z","timestamp":1718323200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>There have been concerns around the use of synthetic mesh for stress urinary incontinence (SUI) surgery with a renewed interest in the use of autologous tissues. Recently, an autologous transobturator sling (aTOT) has been described, but the comparative data with synthetic transobturator sling (sTOT) is limited. The objective of this systematic review and meta\u2010analysis was to assess the outcome of aTOT and compare it with sTOT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A systematic search of PubMed, Scopus, and Web of Science databases was performed and all articles available up to December 31, 2023 were screened. Studies reporting on the outcomes of aTOT and those comparing aTOT with sTOT were included. This review was performed as per Preferred Reporting Items for Systematic Reviews and Meta\u2010analyses guidelines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eleven studies evaluating 323 patients that met the criteria were included in the final analysis, of which 6 were single arm (155 patients) and 5 were comparative. In single\u2010arm studies, the pooled success rate, defined as negative cough stress test at 12 months follow\u2010up was 96.8%, 3.8% had postoperative urinary retention, 6.1% had graft site\u2010related complications and 7.6% required additional intervention for persistent SUI. The overall complication rate was 20.6% and there were no Clavien III\u2013V complications. aTOT had similar success and complication rates when compared with sTOT but had a significantly longer operative time (weighted mean difference: 22.35\u2009min, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.00001) and superior sexual function outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>aTOT, at short\u2010term follow\u2010up (12 months), has similar efficacy and complication rates when compared to sTOT. However, given that the data is limited and not of very good quality, and the fact that long\u2010term follow\u2010up is not available, further studies are required to better define the role of aTOT in the management of female patients with SUI<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.25527","type":"journal-article","created":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T06:31:10Z","timestamp":1718346670000},"page":"2017-2029","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Autologous versus synthetic midurethral transobturator sling: A systematic review and meta\u2010analysis of outcomes"],"prefix":"10.1002","volume":"43","author":[{"given":"Pawan","family":"Vasudeva","sequence":"first","affiliation":[{"name":"Department of Urology Safdarjung Hospital, Vardhaman Mahavir Medical College New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0231-6645","authenticated-orcid":false,"given":"Siddharth","family":"Yadav","sequence":"additional","affiliation":[{"name":"Department of Urology Safdarjung Hospital, Vardhaman Mahavir Medical College New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7090-2091","authenticated-orcid":false,"given":"Sanjay","family":"Sinha","sequence":"additional","affiliation":[{"name":"Department of Urology Apollo Hospital Hyderabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ankit","family":"Raheja","sequence":"additional","affiliation":[{"name":"Department of Mathematics University of Wisconsin\u2013Madison Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9811-5492","authenticated-orcid":false,"given":"Niraj","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Urology Safdarjung Hospital, Vardhaman Mahavir Medical College New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Urology Global Hospital Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,14]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2017.06.061"},{"key":"e_1_2_9_3_1","unstructured":"U.S. Food and Drug Administration. 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