{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T13:58:52Z","timestamp":1762783132934,"version":"3.44.0"},"reference-count":25,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T00:00:00Z","timestamp":1720483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study aimed to assess the efficacy and safety of monoclonal antibody therapies (MATs) for interstitial cystitis\/bladder pain syndrome (IC\/BPS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A systematic search was conducted across databases including PubMed, Embase, <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicalTrial.gov\">clinicalTrial.gov<\/jats:ext-link>, and the Cochrane Library Central Register of Controlled Trials. Randomized controlled trials (RCTs) comparing MATs versus placebo were included. Primary outcomes comprised the Global Response Assessment (GRA) scale and the O'Leary\u2010Sant Interstitial Cystitis Symptom Index (ICSI). Additional analyses encompassed mean daily frequency of voids, the O'Leary\u2010Sant Interstitial Cystitis Problem Index, pain scores, and complications. Statistical analyses were performed using Review Manager 5.3.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Five high\u2010quality RCTs, comprising 263 patients with IC\/BPS, were ultimately selected. MATs were generally effective in treating IC\/BPS. Patients receiving MATs exhibited a higher satisfaction rate (odds ratio [OR]: 2.7, confidence interval [CI]: 1.31\u20135.58, <jats:italic>p<\/jats:italic>\u2009=\u20090.007) and lower ICSI scores (mean difference [MD]: \u22121.44, CI: \u22122.36 to \u22120.52, <jats:italic>p<\/jats:italic>\u2009=\u20090.002). Moreover, MAT recipients experienced reduced pain (MD: \u22120.53, CI: \u22120.79 to \u22120.26, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001) and decreased frequency of urination (MD: \u22121.91, CI: \u22122.55 to \u22121.27, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.00001). Importantly, there were no disparities regarding complication incidence in the MAT and control groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The current findings indicate that MATs are effective and safe for treating IC\/BPS. Nonetheless, future RCTs with larger sample sizes and long\u2010term follow\u2010up are warranted.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.25547","type":"journal-article","created":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T07:22:23Z","timestamp":1720509743000},"page":"1903-1909","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The efficacy and safety of monoclonal antibody therapies for interstitial cystitis\/bladder pain syndrome: A meta\u2010analysis of randomized controlled trials"],"prefix":"10.1002","volume":"43","author":[{"given":"Zhi\u2010Gang","family":"Cao","sequence":"first","affiliation":[{"name":"Department of Urology The 940th Hospital of PLA Joint Logistic Support Force Lanzhou Gansu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fu\u2010Dong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Urology The 940th Hospital of PLA Joint Logistic 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