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Mechanisms for charged and uncharged solutes and water transport across the bladder, mechanism of dAVP toxicity, and utility of urine biomarkers in those with neurological diseases\/nocturia were determined from literature reviews.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Pre\u2010proAVP is present in human\/rodent bladders and may be involved in water reabsorption from bladder that prevents the sensation of fullness for uninterrupted sleep in healthy adults. The mechanism of action of AVP in the CNS was discussed, as was electrolyte\/water transport across the bladder, the basis for dAVP toxicity, and feasibility of urine biomarkers to identify nocturia\/LUTD with neurological diseases.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.25565","type":"journal-article","created":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T05:55:05Z","timestamp":1721886905000},"page":"2300-2307","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A better understanding of basic science may help our management of LUTS\/LUTD in older persons with nocturnal polyuria and nocturia: ICI\u2010RS 2024"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4780-7592","authenticated-orcid":false,"given":"Anthony","family":"Kanai","sequence":"first","affiliation":[{"name":"Department of Medicine, Renal Electrolyte Division University of Pittsburgh Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karel","family":"Everaert","sequence":"additional","affiliation":[{"name":"Department of Urology Ghent University  Gent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Apostolos","family":"Apostolidis","sequence":"additional","affiliation":[{"name":"2ND Department of Urology Aristotle University Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3647-5983","authenticated-orcid":false,"given":"Christopher","family":"Fry","sequence":"additional","affiliation":[{"name":"School of Physiology, Pharmacology &amp; Neuroscience University of Bristol Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pradeep","family":"Tyagi","sequence":"additional","affiliation":[{"name":"Department of Urology University of Pittsburgh Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3159-8012","authenticated-orcid":false,"given":"Andries","family":"Van Huele","sequence":"additional","affiliation":[{"name":"Department of Urology Ghent University  Gent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bahareh","family":"Vahabi","sequence":"additional","affiliation":[{"name":"School of Applied Sciences University of the West of England Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2029-4731","authenticated-orcid":false,"given":"Wendy","family":"Bower","sequence":"additional","affiliation":[{"name":"Melbourne Medical School, Faculty of Medicine, Dentistry and Health Sciences University of Melbourne Melbourne Australia"},{"name":"Department of Physiotherapy Royal Melbourne Hospital Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Wein","sequence":"additional","affiliation":[{"name":"Desai Sethi Institute of Urology, University of Miami Miller School of Medicine  Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2776-2200","authenticated-orcid":false,"given":"Paul","family":"Abrams","sequence":"additional","affiliation":[{"name":"Bristol Urological Institute Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,25]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ackd.2010.04.004"},{"key":"e_1_2_14_3_1","unstructured":"N\u00f8rgaardJP PaulsenF PaulsenO PharmaceuticalsF. 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