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Furthermore, the antagonism of OX<jats:sub>2<\/jats:sub> receptors restored the abnormal levels of overactive bladder markers (i.e., ATP, CGRP, OCT3, TRPV1, ROCK1, and VAChT), diminished neuronal overactivity in central micturition areas (i.e., pontine micturition center, ventrolateral periaqueductal gray, and medial preoptic area) as well as restored the altered hippocampal levels of CRF, cytokines (IL\u20101\u03b2, IL\u20106, IL\u201010, and TNF\u2010\u03b1), and growth factors (BDNF and NGF) that reflected biochemical disturbances detected in depressed people.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>It seems that our findings open new perspectives regarding the implication of the orexin system in the functioning of the urinary bladder and in the pathophysiology of depression.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.25602","type":"journal-article","created":{"date-parts":[[2024,10,15]],"date-time":"2024-10-15T05:39:32Z","timestamp":1728970772000},"page":"229-244","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The Orexin OX<sub>2<\/sub> Receptor\u2010Dependent Pathway Is Implicated in the Development of Overactive Bladder and Depression in Rats Exposed to Corticosterone"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5732-8950","authenticated-orcid":false,"given":"Anna","family":"Serefko","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy and Pharmaceutical Care Faculty of Pharmacy, Medical University of Lublin Lublin 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