{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T18:15:21Z","timestamp":1784139321534,"version":"3.55.0"},"reference-count":46,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T00:00:00Z","timestamp":1730160000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Neurogenic dysfunction of the lower urinary tract is one of the challenging diseases with high burdens in urology. Our study aims to evaluate the efficacy of a 4\u2010week treatment with Solifenacin and Trospium chloride and assess their safety and impact on quality of life.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Following the selection of 206 stroke patients from two centers who met specific eligibility criteria, including a clinical diagnosis of stroke, normal cognitive function, and the presence of lower urinary tract symptoms (LUTS), participants were randomly assigned to receive oral Solifenacin, Trospium chloride, or a placebo. Under the supervision of the Ethics Committee, the baseline characteristics, compliance with medication, and outcomes were monitored, gathered, and analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The majority of participants were male, with a mean age of 67.3, and most had ischemic stroke. The groups had no significant difference in urinary symptoms after stroke. All of the symptoms in the study groups, according to the NBSS questionnaire, were decreased following treatment compared to the baseline (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). After treatment, ICIQ\u2010OAB, and ICIQ\u2010LUTS\u2010QOL total scores and bothersome scores decreased significantly compared to baseline (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). When compared to the placebo, both Trospium chloride and Solifenacin alleviated symptoms according to the NBSS questionnaire and ICIQ\u2010LUTS\u2010QOL, total ICIQ\u2010OAB, and the total score of ICIQ\u2010OAB\u2010Bothersome. However, the total LUTS\u2010QOL\u2010Bothersome score did not change in the active treatment groups compared to the placebo. While comparing the two drugs, these values were similar except for the total score of LUTS\u2010QOL\u2010Bothersome, ICIQ\u2010OAB, and ICIQ\u2010OAB\u2010Bothersome in favor of the Solifenacin group. Moreover, Solifenacin had fewer side effects compared to Trospium chloride or placebo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The study analyzed 206 stroke patients in two international centers and found both drug arms effective in treating overactive bladder. However, inconsistencies were found in efficacy and safety, necessitating further studies with larger populations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Trial Registration<\/jats:title><jats:p>This triple\u2010blind, multicenter, randomized controlled trial was done on 206 stroke patients after getting Ethical Committee approval and registering the project on IRCT (IRCT20160606028304N2).<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.25614","type":"journal-article","created":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T10:38:48Z","timestamp":1730198328000},"page":"85-95","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Safety and Efficacy of Trospium Chloride and Solifenacin in Stroke\u2010Induced Neurogenic Lower Urinary Tract Dysfunction: A Randomized Controlled Trial"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1494-7097","authenticated-orcid":false,"given":"Sakineh","family":"Hajebrahimi","sequence":"first","affiliation":[{"name":"Research Center for Evidence\u2010Based Medicine, Iranian EBM Centre: A JBI Centre of Excellence, Faculty of Medicine Tabriz University of Medical Sciences Tabriz Iran"},{"name":"Urology Department, Faculty of Medicine Tabriz University of Medical Sciences Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7793-0300","authenticated-orcid":false,"given":"Ali","family":"Pourmohammad","sequence":"additional","affiliation":[{"name":"Urology Department, Faculty of Medicine Tabriz University of Medical Sciences Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4689-6899","authenticated-orcid":false,"given":"Charalampos","family":"Konstantinidis","sequence":"additional","affiliation":[{"name":"National Rehabilitation Center Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9424-795X","authenticated-orcid":false,"given":"Michael","family":"Samarinas","sequence":"additional","affiliation":[{"name":"Department of Urology General Hospital of Larissa Larissa Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soroush","family":"Morsali","sequence":"additional","affiliation":[{"name":"Student Research Committee Tabriz University of Medical Sciences Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5596-1771","authenticated-orcid":false,"given":"Hadi","family":"Mostafaei","sequence":"additional","affiliation":[{"name":"Department of Urology, Comprehensive Cancer Center Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi","family":"Farhoudi","sequence":"additional","affiliation":[{"name":"Neurosciences Research Center Tabriz University of Medical Sciences Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1953-7441","authenticated-orcid":false,"given":"Mohammad\u2010Sajjad","family":"Rahnama'i","sequence":"additional","affiliation":[{"name":"Department of Urology St. Elisabeth\u2010Tweesteden Hospital Tilburg The 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